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Behavioral Intervention

Framed Messaging + NRT for Lung Cancer Screening

Phase 2
Waitlist Available
Led By Benjamin Toll, PhD
Research Sponsored by Medical University of South Carolina
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
50 years or older
at least a 20-pack year history of smoking
Must not have
serious arrhythmias
unstable angina pectoris
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 6 month follow-up
Awards & highlights
No Placebo-Only Group

Summary

This trial is testing a new way to help lung cancer patients quit smoking, by framed messaging and nicotine replacement therapy. If successful, this study could help many people quit smoking.

Who is the study for?
This trial is for English-speaking individuals over 50 who currently smoke and have a significant smoking history. They must be willing to be randomly assigned to different treatments. People with recent heart issues, allergies to adhesives, unstable health conditions, or those already in tobacco treatment programs cannot join.
What is being tested?
The study compares two approaches: gain-framed messaging plus Nicotine Replacement Therapy (NRT) versus standard unframed messages about quitting smoking. It's designed for lung cancer screening patients and aims to see which method helps them stop smoking more effectively.
What are the potential side effects?
While the trial primarily focuses on messaging strategies, NRT can cause side effects like skin irritation from patches, sleep problems if used close to bedtime, headache, nausea, dizziness or racing heartbeat.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
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I am 50 years old or older.
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I have smoked at least 20 packs of cigarettes a year.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:
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I have serious heart rhythm problems.
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I have unstable chest pain.
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My heart's function is stable.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~6 month follow-up
This trial's timeline: 3 weeks for screening, Varies for treatment, and 6 month follow-up for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Smoking Cessation - Available Data
Secondary study objectives
Cigarettes Smoked Per Day - Average
Smoking Cessation - Imputed

Awards & Highlights

No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.

Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: Gain-framed MessagingExperimental Treatment1 Intervention
Gain-framed messaging
Group II: Unframed MessagingActive Control1 Intervention
Unframed smoking cessation materials
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Gain-framed messaging
2017
Completed Phase 2
~370

Find a Location

Who is running the clinical trial?

Medical University of South CarolinaLead Sponsor
979 Previous Clinical Trials
7,400,627 Total Patients Enrolled
National Cancer Institute (NCI)NIH
13,958 Previous Clinical Trials
41,112,213 Total Patients Enrolled
Benjamin Toll, PhDPrincipal InvestigatorMedical University of South Carolina
4 Previous Clinical Trials
663 Total Patients Enrolled
Alana Rojewski, PhDStudy DirectorMedical University of South Carolina
1 Previous Clinical Trials
48 Total Patients Enrolled

Media Library

Gain-framed messaging (Behavioral Intervention) Clinical Trial Eligibility Overview. Trial Name: NCT03069924 — Phase 2
Smoking Cessation Research Study Groups: Unframed Messaging, Gain-framed Messaging
Smoking Cessation Clinical Trial 2023: Gain-framed messaging Highlights & Side Effects. Trial Name: NCT03069924 — Phase 2
Gain-framed messaging (Behavioral Intervention) 2023 Treatment Timeline for Medical Study. Trial Name: NCT03069924 — Phase 2
~43 spots leftby Jan 2026
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