Treatment for Kidney Neoplasms

Phase-Based Estimates
1
Effectiveness
1
Safety
UNC Lineberger Comprehensive Cancer Center, Chapel Hill, NC
Kidney Neoplasms+2 More
Eligibility
18+
All Sexes
Eligible conditions
Kidney Neoplasms

Study Summary

This study is evaluating whether a biopsy of a kidney tumor can help determine the best treatment for the patient.

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Eligible Conditions

  • Kidney Neoplasms
  • Kidney Tumors
  • Small Renal Masses (SRM)

Treatment Effectiveness

Study Objectives

This trial is evaluating whether Treatment will improve 2 primary outcomes and 3 secondary outcomes in patients with Kidney Neoplasms. Measurement will happen over the course of 3 years.

3 years
Change in decisional conflict score
Patient-reported anxiety
Patient-reported assessment of communication in cancer care
Patient-reported satisfaction with cancer care
5 years
The concordance of Molecular subtype generated from Clearcode 34 gene set on biopsy tissue compared to nephrectomy samples

Trial Safety

Trial Design

2 Treatment Groups

Biopsy
Placebo group

This trial requires 130 total participants across 2 different treatment groups

This trial involves 2 different treatments. Treatment is the primary treatment being studied. Participants will all receive the same treatment. Some patients will receive a placebo treatment. The treatments being tested are not being studied for commercial purposes.

Biopsy
Procedure
Subjects receive a renal cell biopsy prior to making a decision about treatment
No Biopsy
Other
Subjects do not receive a renal cell biopsy prior to making a decision about treatment

Trial Logistics

Trial Timeline

Approximate Timeline
Screening: ~3 weeks
Treatment: Varies
Reporting: 5 years
This trial has the following approximate timeline: 3 weeks for initial screening, variable treatment timelines, and roughly 5 years for reporting.

Closest Location

UNC Lineberger Comprehensive Cancer Center - Chapel Hill, NC

Eligibility Criteria

This trial is for patients born any sex aged 18 and older. There are 7 eligibility criteria to participate in this trial as listed below.

Mark “yes” if the following statements are true for you:
The patient should have a small renal mass that is less than 7 cm on a cross-sectional radiologic study and should be evaluated at the University of North Carolina Urology or the UNC Cancer Hospital. show original
The text is saying that the person is willing and able to complete patient-reported outcome questionnaires. show original
The person is willing to have extra cores taken from them during a standard of care biopsy procedure show original
In order to test for circulating tumor DNA, the individual is willing to have a blood draw. show original
Ages 18 - 95
The individual has willingly signed authorization forms to allow their health information to be released to the study staff. show original
The school allows surgical specimens to be used for research as long as the students have given consent. show original

Patient Q&A Section

Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is kidney neoplasms?

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There are 5 specific types of kidney neoplasms: kidney cysts are the most common type, accounting for more than half of all neoplasms. Nephroma is an exception to the other types and is the least common type of neoplasms with only about one fourth of all kidney neoplasms. Diagnostic accuracy increases significantly with the enlargement of kidney nodules, while the probability of benign neoplasms is greater than that of malignant neoplasms.

Unverified Answer

What are common treatments for kidney neoplasms?

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The treatment of any solid tumor depends mainly on the tumor type, stage, and overall clinical condition of a patient. Surgery is often necessary for the treatment of kidney neoplasms. Radiotherapy is usually used to treat cancers. Radiation therapy can produce cure for some kidney tumors (such as rhabdomyosarcoma) but has a high rate of developing complications and must be performed only when absolutely necessary. Chemotherapy is usually not a treatment of choice but can be used to treat some kidney tumors. Radiotherapy and chemotherapy are usually more effective than other treatment options, especially for advanced kidney lesions including metastatic lesions. In some cases, kidney tumors may be monitored while waiting for a more effective treatment option.

Unverified Answer

How many people get kidney neoplasms a year in the United States?

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An estimated 25,000 people are diagnosed with a renal cell carcinoma and nearly 8,000 with a renal transitional cell carcinoma per year in the United States. This makes up 3.5% of US adults diagnosed with a neoplasm of the kidney every year.

Unverified Answer

Can kidney neoplasms be cured?

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This article discusses the possibility to cure neoplasms of the kidney. The [cure rate] of [kidney cancer](https://www.withpower.com/clinical-trials/kidney-cancer) is lower than that of other cancers, but its prognosis is good. Nephron-sparing strategies may therefore improve outcomes and decrease the number of cancer patients requiring dialysis.

Unverified Answer

What causes kidney neoplasms?

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Tumor genetics plays a significant role in the development of some kidney neoplasms. Nephron development occurs as a consequence of cell proliferation caused by genetic mutations, environmental toxins, or reactive oxygen species generated by oxidative damage to cells.

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What are the signs of kidney neoplasms?

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It is important to suspect kidney neoplasms due to possible presentation with kidney failure and blood in urine. Ultrasound, CT scan, MRI are the imaging modalities used to diagnose kidney neoplasms.

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What are the latest developments in treatment for therapeutic use?

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At present, the best available treatments for patients with metastatic renal cell carcinoma rely primarily on tyrosine kinase inhibitors such as sorafenib or sunitinib. The use of these drugs has been proven to prolong survival in patients with advanced renal cell carcinoma and has been granted a priority review by Medicare.

Unverified Answer

What are the chances of developing kidney neoplasms?

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Although kidney tumors may be the second most common cancer in males, these data indicate that kidney tumors do not constitute a predisposing factor for developing bladder neoplasms.

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What is the primary cause of kidney neoplasms?

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The most common primary diagnosis associated with AKI was none (37%); most cases were CKD- and AKI-related (29%); most cases of AKI had a primary diagnosis of AKI-related (13%).

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Does treatment improve quality of life for those with kidney neoplasms?

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All measured quality of life parameters improved after treatment for NS, but this improvement could not be correlated with disease stage or size. However, we were able to demonstrate that an overall improvement in QOL for patients with KN can be achieved using a combination of medical and psychosocial treatment.

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Have there been any new discoveries for treating kidney neoplasms?

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Nephron-sparing surgeries are feasible. They can be performed in both unilateral and bilateral nephron-sparing kidney. Even though the renal function usually decrease after unilateral surgery, kidney function can be maintained through the meticulous choice of the surgical strategy (partial nephrectomy) and careful postoperative care. To preserve the renal function as much as possible, it is important to perform the operations as early as possible. Furthermore, renal metastasis may recur after nephron-sparing surgery. To prevent this recurrence, early identification of renal metastasis and early diagnosis are very important.

Unverified Answer

What is the average age someone gets kidney neoplasms?

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The average age people get kidney neoplasms in the United States is 64, and this is expected to increase as the population ages in spite of declines in smoking and obesity and increases in occupational and environmental exposure, including passive smoking. The data indicate that the average age at diagnosis of the three most common types of kidney neoplasms is 58 for men and 68 for women with a 2- to 3fold increase in the incidence of each type from 2010 to 2015.

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