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Ultrasound

Portable Ultrasound for Stroke Diagnosis (CUPID_EMS Trial)

N/A
Waitlist Available
Led By Aarti Sarwal, MD
Research Sponsored by Wake Forest University Health Sciences
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
18 years old or older
Transfer initiated by EMS to the ED for further evaluation
Must not have
Less than 18 years old
Penetrating cranial/head trauma or scalp wound
Timeline
Screening 3 weeks
Treatment Varies
Follow Up year 1
Awards & highlights
No Placebo-Only Group

Summary

This trial aims to see if EMS personnel can use portable ultrasound to quickly diagnose brain bleeding in stroke patients by sending images to a remote doctor for interpretation.

Who is the study for?
This trial is for adults who EMS providers think might be having a stroke or brain hemorrhage, and are being taken to the emergency department. It's not for people under 18, prisoners, those with head injuries from penetration or scalp wounds, or if an ultrasound could interfere with their care.
What is being tested?
The study is testing whether paramedics can use a portable ultrasound device (cPOCUS) on the way to the hospital to diagnose acute bleeding inside the brain (ICH).
What are the potential side effects?
There are generally no side effects associated with cranial point of care ultrasounds as they are non-invasive imaging tests. However, there may be discomfort due to pressure from the ultrasound probe.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
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I am 18 years old or older.
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I was brought to the emergency department by ambulance for further checks.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:
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I am under 18 years old.
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I have had a serious head injury or scalp wound.
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Ultrasound procedures are not suitable for my care.
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I choose not to go to the emergency department.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~year 1
This trial's timeline: 3 weeks for screening, Varies for treatment, and year 1 for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Success Rate for cPOCUS Exams

Awards & Highlights

No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.

Trial Design

1Treatment groups
Experimental Treatment
Group I: Cranial Point of Care UltrasoundExperimental Treatment1 Intervention
Cranial ultrasound involves 2-dimensional B mode imaging of the brain parenchyma in the axial plane
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Cranial Point of Care Ultrasound
2022
N/A
~90

Research Highlights

Information in this section is not a recommendation. We encourage patients to speak with their healthcare team when evaluating any treatment decision.
Mechanism Of Action
Side Effect Profile
Prior Approvals
Other Research
Common treatments for stroke, particularly ischemic stroke, include thrombolytics like tissue plasminogen activator (tPA), which works by dissolving blood clots to restore blood flow to the brain. For hemorrhagic stroke, treatments focus on controlling bleeding and reducing intracranial pressure, often involving medications like antihypertensives and surgical interventions such as craniotomy. The use of cPOCUS by EMS can rapidly diagnose ICH, allowing for quicker decision-making and appropriate treatment initiation, which is crucial for improving outcomes and reducing long-term disability in stroke patients.

Find a Location

Who is running the clinical trial?

Wake Forest University Health SciencesLead Sponsor
1,397 Previous Clinical Trials
2,460,049 Total Patients Enrolled
17 Trials studying Stroke
14,539 Patients Enrolled for Stroke
Aarti Sarwal, MDPrincipal InvestigatorWake Forest University Health Sciences
4 Previous Clinical Trials
1,295 Total Patients Enrolled
1 Trials studying Stroke
200 Patients Enrolled for Stroke

Media Library

Cranial Point of Care Ultrasound (Ultrasound) Clinical Trial Eligibility Overview. Trial Name: NCT05492474 — N/A
~25 spots leftby Dec 2025