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Glycocalyx for Brain Aneurysm

N/A
Waitlist Available
Led By Daniel Theodore, MD
Research Sponsored by University of Virginia
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up day 0 through day13
Awards & highlights

Study Summary

This study will provide novel information to the literature base for the pathophysiology of aneurysmal subarachnoid hemorrhage. The association of breakdown products in the serum of aSAH patients were reported in a very small case series of 3 patients, as mentioned above. However, while their results are intriguing and encouraging, our study will provide more definitive information about the GC in aSAH. If there is a positive correlation, the results of this study will guide future investigations into new therapies for this devastating disease such as MMP inhibition with doxycycline.

Eligible Conditions
  • Brain Aneurysm

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~day 0 through day13
This trial's timeline: 3 weeks for screening, Varies for treatment, and day 0 through day13 for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Syndecan-1 and heparin sulfate
Secondary outcome measures
serum Matrix metalloproteinase-1 and Matrix metalloproteinase-9
urinary microalbumin-to-creatinine ratio (MACR)

Trial Design

1Treatment groups
Experimental Treatment
Group I: GlycocalyxExperimental Treatment1 Intervention
degree of glycocalyx breakdown in patients with aSAH

Find a Location

Who is running the clinical trial?

University of VirginiaLead Sponsor
756 Previous Clinical Trials
1,245,264 Total Patients Enrolled
Daniel Theodore, MDPrincipal InvestigatorUniversity of Virginia

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
European Heart JournalJournal
Early Short-term Doxycycline Therapy in Patients with Acute Myocardial Infarction and Left Ventricular Dysfunction to Prevent the Ominous Progression to Adverse Remodelling: The TIPTOP Trial
Cerisano, G., P. Buonamici, R. Valenti, R. Sciagra, S. Raspanti, A. Santini, N. Carrabba, et al.. 2013. “Early Short-term Doxycycline Therapy in Patients with Acute Myocardial Infarction and Left Ventricular Dysfunction to Prevent the Ominous Progression to Adverse Remodelling: The TIPTOP Trial”. European Heart Journal. Oxford University Press (OUP). doi:10.1093/eurheartj/eht420.
clinicaltrials.govStudy
Degradation of the Glycocalyx in Delayed Cerebral Ischemia After Aneurysmal Subarachnoid Hemorrhage
Danny Theodore, MD 2018. "Degradation of the Glycocalyx in Delayed Cerebral Ischemia After Aneurysmal Subarachnoid Hemorrhage". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT03706768.
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~6 spots leftby May 2025
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