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Exercise trial for Connective Tissue
Study Summary
The proposed study aims to shed light on the function/importance/relevance of exercise-induced changes in exosomes to connective tissues. Exosomes are known to increase robustly in response to exercise. We have previously shown that serum isolated from subjects after they lift heavy weights increases human engineered ligament collagen content and mechanics more than serum from before they lift weight. Further, we showed that exercise-induced changes in hormones could not explain the change in ligament structure or function. These data indicate that there is a significant gap in our understanding of muscle-connective tissue crosstalk. To address this gap, the current proposal seeks to: i) isolate and sequence exosomal RNA (long non-coding, miR, and mRNA) and ii) determine whether exosomes isolated from serum after exercise increase engineered ligament mechanics and collagen content.
- Connective Tissue
- Exosomes
- Exercise
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Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Trial Design
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Frequently Asked Questions
Am I eligible to join this research initiative?
"This clinical study seeks 12 individuals, aged 18 to 35, with a history of exercise (>1y) and no underlying health conditions. Additionally, they must possess exosomes at the time of enrollment."
Is the recruitment phase for this experiment still open?
"Clinicaltrials.gov data indicates that this research effort, first launched on November 7th 2022, is currently recruiting participants. The study was last updated on the same day as its initial posting."
Are individuals below the age of 65 eligible to partake in this investigation?
"This trial has stipulated that participants must be between 18 and 35 years old."
How many participants is this clinical trial accepting at its maximum capacity?
"Correct. Clinicaltrials.gov confirms that this medical experiment, which was initially posted on November 7th 2022, is actively recruiting participants. A total of 12 patients need to be found from a single research centre."
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