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Brain Substrate Switch for Metabolic Diseases and Age-Related Issues (BSS Trial)

N/A

Waitlist Available

Research Sponsored by University of British Columbia

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be between 18 and 65 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up data collected at rest, during graded infusions of lactate and ketones, pre- and post- 6 minutes of high-intensity cycling exercise

Awards & highlights

BSS Trial Summary

This trial will investigate if switching brain fuel sources during fasting and exercise benefits the brain. Healthy participants will fast/exercise and receive infusions to isolate the brain's metabolic flexibility. Brain biomarkers BDNF and sAPPA will be measured.

Who is the study for?

This trial is for young, healthy individuals who are regularly physically active. It's not suitable for smokers, those on daily prescription meds that affect exercise response, women with menstrual irregularities or who are pregnant/post-menopausal, obese individuals (BMI over 30), or anyone with diseases that complicate exercise.Check my eligibility

What is being tested?

The study tests how the brain switches from using glucose to ketones and lactate during fasting and high-intensity cycling. Participants will fast for three days and perform intense exercise; they'll also receive infusions of ketones and lactate to mimic these states without actual fasting or exercising.See study design

What are the potential side effects?

Potential side effects may include discomfort from fasting such as headaches or dizziness, muscle soreness from high-intensity cycling, and possible reactions at the infusion site like redness or swelling.

BSS Trial Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ data collected at rest, during graded infusions of lactate and ketones, pre- and post- 6 minutes of high-intensity cycling exercise

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~data collected at rest, during graded infusions of lactate and ketones, pre- and post- 6 minutes of high-intensity cycling exercise

This trial's timeline: 3 weeks for screening, Varies for treatment, and data collected at rest, during graded infusions of lactate and ketones, pre- and post- 6 minutes of high-intensity cycling exercise for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Brain-derived neurotrophic factor, secreted amyloid beta precursor protein

Secondary outcome measures

Brain substrate metabolism

BSS Trial Design

2Treatment groups

Experimental Treatment

Active Control

Group I: FastedExperimental Treatment1 Intervention

Exercise and passive infusions of ketones and lactate in the fasted state. Participants will be required to fast for 72 hours prior to arriving to the lab for this testing arm.

Group II: FedActive Control1 Intervention

Exercise and passive infusions of ketones and lactate in the fed state. Participants will be fed a small meal in the middle of the protocol, also.

Do I qualify?Apply below to find out

Find a Location

Who is running the clinical trial?

University of British ColumbiaLead Sponsor

1,413 Previous Clinical Trials

2,466,949 Total Patients Enrolled

1 Trials studying Metabolic Diseases

23 Patients Enrolled for Metabolic Diseases

University of OtagoOTHER

35 Previous Clinical Trials

39,704 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Does the criteria for this trial accommodate individuals aged 35 or above?

"Conforming to the conditions of participation, this clinical trial mandates that participants be between 19 and 40 years of age."

Answered by AI

Who is entitled to join this experiment?

"This medical trial requires 12 volunteers who have metabolic diseases and are between 19 to 40 years of age."

Answered by AI

Is this medical study still available to new participants?

"According to the recent information on clinicaltrials.gov, this study is no longer in search of participants. Initially posted on October 1st 2023 and last updated on August 22nd 2023, it appears that although this particular trial isn't open for recruitment presently, there remain 127 other studies actively seeking patients."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

Brain Substrate Switch to Ketones and Lactate

Phil Ainslie 2023. "Brain Substrate Switch to Ketones and Lactate". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT06000605.