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Resistance vs Endurance Exercise for Osteoporosis (MOVE Trial)

N/A
Recruiting
Led By Sarah J Wherry, PhD
Research Sponsored by VA Office of Research and Development
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up serum tca is measured before exercise (-15, 0 minutes) and after exercise (60, 120, 300 minutes and 24 and 48 hours).
Awards & highlights

MOVE Trial Summary

This trial will compare how two types of exercise affect bone resorption in adults. It is not known if resistance exercise causes a similar increase in bone resorption as endurance exercise, or if exercise training affects the increase in bone resorption following exercise for both endurance and resistance exercise.

Who is the study for?
This trial is for healthy older veterans aged 60+ in the Denver area who are normally active, like walking or cycling. They can't join if they have liver disease, kidney problems, anemia, diabetes, thyroid issues, abnormal calcium levels, severe high blood pressure, recent COVID-19 symptoms or diagnosis, a fracture within the last six months or heart disease.Check my eligibility
What is being tested?
The study tests how two types of exercise affect bone health markers in older adults. Participants will do either 10 weeks of supervised resistance training (like lifting weights) or endurance training (like running), to see which one is better for bones.See study design
What are the potential side effects?
While not explicitly stated for this trial since it's about exercise interventions rather than medications; potential side effects may include muscle soreness and fatigue from resistance exercises and joint impact concerns from endurance activities.

MOVE Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~serum ica is measured before exercise (-15, 0 minutes) and after exercise (60, 120, 300 minutes and 24 and 48 hours),
This trial's timeline: 3 weeks for screening, Varies for treatment, and serum ica is measured before exercise (-15, 0 minutes) and after exercise (60, 120, 300 minutes and 24 and 48 hours), for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
6-minute walk test
Procollagen 1 intact N-terminal propeptide (P1NP)
Short Physical Performance Battery (SPPB)
+1 more
Secondary outcome measures
Ionized calcium (iCa)
Parathyroid Hormone (PTH)
Total calcium (tCa)
Other outcome measures
1-repetition maximum (1RM)
VO2peak from graded exercise test (GXT)

MOVE Trial Design

2Treatment groups
Experimental Treatment
Group I: Resistance ExerciseExperimental Treatment1 Intervention
Participants will perform total body resistance training 3x per week for 10 weeks. Each exercise session will last approximately 1 hour.
Group II: Endurance ExerciseExperimental Treatment1 Intervention
Participants will complete 60 minutes of stationary cycling 3x per week at 70-80% of maximal heart rate for 10 weeks.

Find a Location

Who is running the clinical trial?

VA Office of Research and DevelopmentLead Sponsor
1,609 Previous Clinical Trials
3,306,309 Total Patients Enrolled
University of Colorado, DenverOTHER
1,735 Previous Clinical Trials
2,149,051 Total Patients Enrolled
Sarah J Wherry, PhDPrincipal InvestigatorRocky Mountain Regional VA Medical Center, Aurora, CO
3 Previous Clinical Trials
107 Total Patients Enrolled

Media Library

10 Weeks of Supervised Endurance Exercise Training Clinical Trial Eligibility Overview. Trial Name: NCT05266976 — N/A
Musculoskeletal Disorders Research Study Groups: Resistance Exercise, Endurance Exercise
Musculoskeletal Disorders Clinical Trial 2023: 10 Weeks of Supervised Endurance Exercise Training Highlights & Side Effects. Trial Name: NCT05266976 — N/A
10 Weeks of Supervised Endurance Exercise Training 2023 Treatment Timeline for Medical Study. Trial Name: NCT05266976 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is there still capacity for participants in this investigation?

"Affirmative. Current information on clinicaltrials.gov confirms that this research, which was first posted on July 6th 2022 is actively seeking participants. Up to 120 patients need to be recruited from 1 different healthcare facility."

Answered by AI

What is the overall enrollment of participants in this clinical trial?

"Affirmative. Clinicaltrials.gov corroborates that this clinical trial, which first went live on July 6th 2022, is presently searching for suitable participants. The study requires 120 patients from a single medical centre to be enrolled in the experiment."

Answered by AI

Who else is applying?

What state do they live in?
Oregon
How old are they?
18 - 65
What portion of applicants met pre-screening criteria?
Met criteria
Recent research and studies
clinicaltrials.govStudy
Mode of Exercise and Bone Biomarkers in Older Veterans
2022. "Mode of Exercise and Bone Biomarkers in Older Veterans". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT05266976.
All > Osteoporosis
~72 spots leftby Dec 2026
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