CLINICAL TRIAL

10 Weeks of Supervised Endurance Exercise Training for Musculoskeletal Diseases

Waitlist Available · 18+ · All Sexes · Aurora, CO

Mode of Exercise and Bone Biomarkers in Older Veterans

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About the trial for Musculoskeletal Diseases

Eligible Conditions
Musculoskeletal Diseases · Aging · Osteoporosis

Treatment Groups

This trial involves 2 different treatments. 10 Weeks Of Supervised Endurance Exercise Training is the primary treatment being studied. Participants will be divided into 2 treatment groups. There is no placebo group. The treatments being tested are not being studied for commercial purposes.

Experimental Group 1
10 Weeks of Supervised Endurance Exercise Training
BEHAVIORAL
Experimental Group 2
10 Weeks of Supervised Resistance Exercise Training
BEHAVIORAL

Eligibility

This trial is for patients born any sex aged 18 and older. There are 2 eligibility criteria to participate in this trial as listed below.

Inclusion & Exclusion Checklist
Mark “yes” if the following statements are true for you:
Healthy older (60+ y) Veteran women and men in the Denver Metro Area
You are normally active. show original
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Odds of Eligibility
Unknown<50%
Be sure to apply to 2-3 other trials, as you have a low likelihood of qualifying for this one.Apply To This Trial
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Approximate Timelines

Please note that timelines for treatment and screening will vary by patient
Screening: ~3 weeks
Treatment: varies
Reporting: Serum iCa is measured before exercise (-15, 0 minutes) and after exercise (60, 120, 300 minutes and 24 and 48 hours),
Screening: ~3 weeks
Treatment: Varies
Reporting: Serum iCa is measured before exercise (-15, 0 minutes) and after exercise (60, 120, 300 minutes and 24 and 48 hours),
This trial has approximate timelines as follows: 3 weeks for initial screening, variable treatment timelines, and reporting: Serum iCa is measured before exercise (-15, 0 minutes) and after exercise (60, 120, 300 minutes and 24 and 48 hours),.
View detailed reporting requirements
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- What options you have available- The pros & cons of this trial
- Whether you're likely to qualify- What the enrollment process looks like

Measurement Requirements

This trial is evaluating whether 10 Weeks of Supervised Endurance Exercise Training will improve 4 primary outcomes, 3 secondary outcomes, and 2 other outcomes in patients with Musculoskeletal Diseases. Measurement will happen over the course of Change in Short Physical Performance Battery score from the beginning to the end of the 10 week exercise intervention..

Short Physical Performance Battery (SPPB)
CHANGE IN SHORT PHYSICAL PERFORMANCE BATTERY SCORE FROM THE BEGINNING TO THE END OF THE 10 WEEK EXERCISE INTERVENTION.
The Short Physical Performance Battery will be performed at the beginning and the end of the intervention to assess physical function. Scores range from 0 to 12. Higher scores generally indicate better physical function.
CHANGE IN SHORT PHYSICAL PERFORMANCE BATTERY SCORE FROM THE BEGINNING TO THE END OF THE 10 WEEK EXERCISE INTERVENTION.
Parathyroid Hormone (PTH)
THE CHANGE IN SERUM PTH FROM BEFORE EXERCISE TO THE PEAK FOLLOWING EXERCISE FOLLOWING EACH EXERCISE TEST. PEAK COULD OCCUR UP TO 48 HOURS FOLLOWING EXERCISE.
Parathyroid hormone is a blood marker of parathyroid function. Parathyroid hormone helps to regulate blood calcium levels. The reference range is 14 to 65 pg/mL, with levels in range suggesting normal parathyroid function.
THE CHANGE IN SERUM PTH FROM BEFORE EXERCISE TO THE PEAK FOLLOWING EXERCISE FOLLOWING EACH EXERCISE TEST. PEAK COULD OCCUR UP TO 48 HOURS FOLLOWING EXERCISE.
c-telopeptide of type 1 collagen (CTX) change
BEFORE EXERCISE TO UP TO 48 HOURS AFTER EACH EXERCISE BOUT
CTX is a marker of bone resorption. Reference range is 0.1-0.8 ng/mL with lower concentrations suggesting less bone resorption
BEFORE EXERCISE TO UP TO 48 HOURS AFTER EACH EXERCISE BOUT
1-repetition maximum (1RM)
CHANGE IN LEG PRESS 1RM FROM THE BEGINNING TO THE END OF THE 10 WEEK EXERCISE INTERVENTION.
1RM of leg press will be measured at the beginning and the end of the 10 week exercise intervention to measure muscle strength. Higher weights performed during the test indicated greater muscle strength.
CHANGE IN LEG PRESS 1RM FROM THE BEGINNING TO THE END OF THE 10 WEEK EXERCISE INTERVENTION.
VO2peak from graded exercise test (GXT)
CHANGE IN VO2 PEAK FROM THE BEGINNING TO THE END OF THE 10 WEEK EXERCISE INTERVENTION.
A cycling GXT will be performed at the beginning and the end of the exercise intervention to measure aerobic fitness. Higher values represent greater aerobic fitness.
CHANGE IN VO2 PEAK FROM THE BEGINNING TO THE END OF THE 10 WEEK EXERCISE INTERVENTION.
6-minute walk test
CHANGE IN THE DISTANCE COVERED IN THE 6-MINUTE WALK TEST FROM THE BEGINNING TO THE END OF THE10 WEEK EXERCISE INTERVENTION.
The 6-minute walk test will be performed at the beginning and the end of the intervention to assess physical function and fitness. Greater distances covered during the 6 minute walk test generally represent greater function and fitness.
CHANGE IN THE DISTANCE COVERED IN THE 6-MINUTE WALK TEST FROM THE BEGINNING TO THE END OF THE10 WEEK EXERCISE INTERVENTION.
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Patient Q & A Section

Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is osteoporosis?

Osteoporosis is a disease that occurs in women after menopause, and young boys and girls, who have experienced a sudden or sudden acceleration of bone loss.

Anonymous Patient Answer

Can osteoporosis be cured?

Current therapies are effective in reducing fracture risk, but they do not modify the rate of bone loss even in patients with established osteoporosis. Thus, the goal of medical treatment should be to reduce fracture risk, without altering bone mineral density or the rate of bone loss.

Anonymous Patient Answer

What are common treatments for osteoporosis?

Treatment options for osteoporosis include calcium supplements, bisphosphonates, and hormone replacement therapy. These treatments are given to symptomatic persons as well as for the purpose of preventing osteoporosis. Osteoporosis may be prevented through lifestyle and behavioral modifications.

Anonymous Patient Answer

How many people get osteoporosis a year in the United States?

Approximately 33 million women and men in the United States, ages 55 and older, have OP. A higher education attainment decreases the risk of OP in all age groups and among both females and males. For all age groups, postmenopausal women have the lowest risk of OP.

Anonymous Patient Answer

What causes osteoporosis?

The lack of vitamin D in winter may play a role in bone loss associated with osteoporosis. Low dietary calcium (e.g., <500 mg/day) appears to be linked to osteoporosis, but further research in this area has been challenging.

Anonymous Patient Answer

What are the signs of osteoporosis?

Signs of osteoporosis may include feeling a strong, persistent, and ongoing need to stand up with one leg in the morning for a while as opposed to standing up or sitting down gradually.\n

Anonymous Patient Answer

Is 10 weeks of supervised resistance exercise training safe for people?

Recent findings demonstrates the safety of a 10-week resistance exercise program for healthy middle-aged men and women. Ten minutes of strength/sprint endurance training per day at an intensity of around 75-85 % one-repetition max. is recommended for health benefits in healthy middle-aged and older people.

Anonymous Patient Answer

What is the average age someone gets osteoporosis?

The average age of those who get osteoporosis or who are at risk for osteoporosis is 65, the same as that for older adults in general. Osteoporosis is a common condition, affecting more than 8 percent of women aged 60 and more and more than half of women over the age of 80. The most common sites of osteonecrosis in postmenopausal women are the vertebrae, femur, and hip. The term vertebral fragility fracture may be used to refer specifically to vertebral osteoporotic changes rather than to osteoporotic vertebral instability.

Anonymous Patient Answer

What is the primary cause of osteoporosis?

In a recent study, findings identified a high prevalence of anemia among the osteoporotic population. This finding can possibly be related to the anemia associated with Vitamin D deficiency.

Anonymous Patient Answer

Does 10 weeks of supervised resistance exercise training improve quality of life for those with osteoporosis?

The majority of patients in this study reported a significant improvement in general and specific health-related QoL after 10 weeks of resistance exercise training program for osteoporosis.

Anonymous Patient Answer

How does 10 weeks of supervised resistance exercise training work?

Ten weeks of supervised RT is superior to free-weights for restoring bone density in elderly men and women after 1 year. There is a need to address a critical knowledge gap for clinicians and educators concerning RT, such as the level of intensity and volume-intensity of training necessary to achieve significant results.

Anonymous Patient Answer

Has 10 weeks of supervised resistance exercise training proven to be more effective than a placebo?

10 weeks of home-based high-intensity resistance exercise training resulted in significant improvements in trabecular micro-hardness, cancellous volumetric bone density and other bone structural parameters compared with a placebo. These changes occurred over a 4-week baseline training phase.

Anonymous Patient Answer
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