← Back to Search

Xenon MRI for Chronic Lung Disease

N/A

Recruiting

Led By Grace E Parraga, PhD

Research Sponsored by Western University, Canada

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Subject must be able to perform a breathhold for 16s

Subject able to perform reproducible pulmonary function testing (i.e., the 3 best acceptable spirograms have Forced Expiratory Volume at one second (FEV1) values that do not vary more than 5% of the largest value or more than 100 ml, whichever is greater)

Timeline

Screening 3 weeks

Treatment Varies

Follow Up 5 years

Awards & highlights

Study Summary

This trial will use MRI and Pulmonary Function tests to develop tools to measure lung health in people aged 18-85 with lung disease.

Who is the study for?

This trial is for adults aged 18-85 with lung diseases like asthma, COPD, or pulmonary fibrosis. Participants must be able to understand the study and consent to it, have a certain level of lung function (FEV1 >25% predicted), and be in stable health. They can't join if they're pregnant, have MRI-incompatible devices in their body, severe claustrophobia, oxygen saturation too low, or conditions preventing them from performing required tests.Check my eligibility

What is being tested?

The trial involves using a special type of MRI called hyperpolarized Xenon 129 MRI along with Pulmonary Function testing. These tools will help measure different aspects of lung function such as gas exchange and airway obstruction in people with chronic lung disease.See study design

What are the potential side effects?

Since this trial uses non-invasive imaging technology without drugs or surgery, side effects are minimal but may include discomfort from holding breath during the scan or anxiety due to being in an enclosed space during the MRI.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Select...

I can hold my breath for 16 seconds.

Select...

I can perform lung function tests with consistent results.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ 5 years

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~5 years

This trial's timeline: 3 weeks for screening, Varies for treatment, and 5 years for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Ventilation Defect Percent (VDP) of the lung

Secondary outcome measures

Apparent Diffusion Coefficients (ADC) of the lung

Dissolved phase spectroscopy measurements

Side effects data

From 2020 Phase 3 trial • 38 Patients • NCT03417687

Pruritus

Hematemesis

Hypoaesthesia oral

Hair disorder

Erythema

Intestinal pseudo-obstruction

Lacrimation increased

Colitis

Nausea

Eye pruritus

Restlessness

Skin discolouration

100%

80%

60%

40%

20%

Study treatment Arm

129Xe Before 133Xe

133Xe Before 129Xe

Trial Design

1Treatment groups

Experimental Treatment

Group I: MRI at baseline and over timeExperimental Treatment1 Intervention

Patients with chronic lung disease will undergo pulmonary function tests, hyperpolarized Xenon MRI at each visit.

0 / 2Eligibility criteria met

Find a Location

Who is running the clinical trial?

Western University, CanadaLead Sponsor

239 Previous Clinical Trials

56,821 Total Patients Enrolled

Grace E Parraga, PhDPrincipal InvestigatorRobarts Research Institute, The University of Western Ontario

14 Previous Clinical Trials

1,264 Total Patients Enrolled

Media Library

MRI at baseline and over time Clinical Trial Eligibility Overview. Trial Name: NCT02723500 — N/A

Lung Disease Research Study Groups: MRI at baseline and over time

Lung Disease Clinical Trial 2023: MRI at baseline and over time Highlights & Side Effects. Trial Name: NCT02723500 — N/A

MRI at baseline and over time 2023 Treatment Timeline for Medical Study. Trial Name: NCT02723500 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Could elderly individuals aged seventy-five and older be considered for this research endeavor?

"This study welcomes individuals aged 18 and up to 85 years old as potential candidates."

Answered by AI

Do I satisfy the criteria for joining this experimental study?

"To qualify for this medical trial, prospective participants must have a pulmonary disorder and be aged between 18-85. This research is aiming to recruit roughly 100 individuals."

Answered by AI

How many individuals have taken part in the trial thus far?

"Affirmative. According to clinicaltrials.gov, the recruitment process for this medical trial is ongoing; it was first listed on August 1st 2011 and updated most recently on May 10th 2023. The study requires 100 participants at two different facilities."

Answered by AI

Is this research project still recruiting participants?

"As documented on clinicaltrials.gov, this trial is presently recruiting participants. The study was opened for registration on August 1st 2011 and last edited in May 10th 2023."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

129 Xenon MRI in Chronic Lung Disease

Dr. Grace Parraga 2011. "129 Xenon MRI in Chronic Lung Disease". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT02723500.

All > Lung Disease