This trial is evaluating whether Hydrocortisone will improve 1 primary outcome in patients with Disease. Measurement will happen over the course of Baseline, and 3 hours post-hydrocortisone.
This trial requires 80 total participants across 1 different treatment group
This trial involves a single treatment. Hydrocortisone is the primary treatment being studied. Participants will all receive the same treatment. There is no placebo group. The treatments being tested are in Phase < 1 and are in the first stage of evaluation with people.
"There are many factors that lead to the development of a disease. These include genetic factors, health problems, environmental exposures, and age. It is important to diagnose and recognize the disease before it leads to serious health problems, and proper treatment is necessary to prevent and manage the disease." - Anonymous Online Contributor
"Disease is a collection of signs and symptoms caused by the physiological, anatomic, or pathogenic processes of a disease. The definition of disease requires the consideration that the disease is only the disease that is diagnosed in the individual. Therefore, 'the diseased' always exists in a medical context. Because most diseases are characterized by their symptoms rather than their cause, this concept of the diseased can be applied to other medical or biological conditions. However, the term 'disease' can also apply to many specific, transient, or nonfunctional conditions that cause signs and symptoms; in this context, disease may be understood as a condition that occurs in individuals who are under the care of a clinic, for example a health center." - Anonymous Online Contributor
"In general, the disease is not curable, but some patients or disease processes can be treated to control symptoms. An example of such was the treatment of the symptoms in patients with a life-threatening cardiac disorder or a life-threatening cancer. Thus, the problem of cure cannot be defined in terms of whether symptoms are cured." - Anonymous Online Contributor
"When signs and symptoms of a disease are described, a high level of evidence is required to assess a patient's probability of the disease. For any particular sign and symptom, one must consider the probability that a patient has a disease that can cause that sign and symptom. It is only after a complete physical examination that one can start to decide a particular patient has disease. In general, there are no definitive signs of disease. However, there are some signs which are commonly associated with diseases and should not be assumed to be disease signs. These signs are listed below.\n\n- An increase in the size or consistency of a lymph node." - Anonymous Online Contributor
"The number of cases of diabetes and cardiovascular disease increased between 1978 and 1999, while the number of cases of kidney disease did not increase in this period. The most common diseases were arteriosclerotic heart disease, cerebrovascular stroke, chronic kidney disease, diabetes, chronic liver disease, cancer and COPD." - Anonymous Online Contributor
"Common treatments include a variety of agents used in other diseases, such as anti-inflammatories, anti-hypertensives, anti-hypertensive drugs, antipsychotics and anti-anxiety drugs. The most common treatment used in other fields is often the treatment of choice for this disease or condition as well." - Anonymous Online Contributor
"Hydrocortisone is a glucocorticoid and inhibits the hypothalamic-pituitary-adrenal axis by inducing the synthesis of corticosteroid hormones in the adrenal gland. It also increases the turnover of glucocorticoid precursors in the central nervous system. Thus, by decreasing the release of ACTH and by enhancing the production of glucocorticoid hormones in the adrenal gland, hydrocortisone acts as a glucocorticoid. A rise in the circulating concentrations of cortisone and cortisol may also be associated with the increase in ACTH. Nevertheless, other mechanisms may also contribute to the treatment with glucocorticoids." - Anonymous Online Contributor
"The high level of patient compliance with hydrocortisone is probably because the tablets are so easy to take. This information is useful for clinicians who can make the first decision about whether to prescribe hydrocortisone in a patient with unexplained IBS." - Anonymous Online Contributor
"Patients treated with oral hydrocortisone compared with patients treated with placebo improved significantly in all aspects of QOL. The use of oral hydrocortisone can improve the QOL of patients with severe and recalcitrant disease." - Anonymous Online Contributor
"The two major causes of disease are thought to be: environmental vs genetic. What we observe in people is indicative of a combination between the genetic and environmental sources. The genetic component plays a more important role in the cause of the diseases. But we can say that in the case of the diseases, in particular the cancers, the environmental component is dominant. To summarize, genetics and environmental effects in combination, seem the main causes of most diseases." - Anonymous Online Contributor
"There are no conclusive explanations regarding the origin of familial cases. Some researchers have suggested that some hereditary factors predispose, whilst others confer immunity to, some cancers. Results from a recent paper has only one report of an individual with P53 mutations. Further research is needed to investigate the frequency of different cancers in kindred in which at least one relative has had that type of cancer. Copyright 2004 John Wiley & Sons, Ltd." - Anonymous Online Contributor
"There are many anecdotal reports of adverse effects of hydrocortisone usage. We are unable to demonstrate a statistically significant increased rate of adverse effects in this study when compared to placebo." - Anonymous Online Contributor