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Atezolizumab + Chemo-Immunotherapy for Diffuse Large B-Cell Lymphoma
Study Summary
This trial is testing a combination of immunotherapy and chemotherapy drugs to treat patients with a certain type of lymphoma that has returned or does not respond to treatment.
Timeline
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Side effects data
From 2019 Phase 3 trial • 1225 Patients • NCT02008227Trial Design
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Who is running the clinical trial?
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- I am 18 years old or older.I can take care of myself but might not be able to do heavy physical work.My lymphoma has changed into a more aggressive type known as DLBCL.I have a significant liver condition.My white blood cell count is healthy, unless my bone marrow is affected by lymphoma.You should have a platelet count of at least 75,000/mcL, unless you have lymphoma that has spread to your bone marrow.My hemoglobin level is at least 8 g/dL or my low level is due to lymphoma in my bone marrow.I can take care of myself but might not be able to do active work.I am HIV-positive, on stable HAART, with no current infections needing antibiotics or antifungals, a CD4 count over 250, and an undetectable viral load.I have had a bone marrow or solid organ transplant in the past.I have been treated with drugs targeting PD-1 or PD-L1.My lymphoma has spread to my brain or spinal cord.I have not received a live vaccine in the last 4 weeks and do not plan to during or up to 5 months after the study.I haven't taken any immune-boosting drugs in the last 6 weeks.I have not met the specific requirements for anti-CTLA-4 treatment.I haven't taken any immune-weakening drugs in the last 2 weeks.I haven't had major surgery in the last 28 days and don't expect to need one during the study.My condition worsened or didn't respond after my first treatment.I haven't had chemotherapy or radiotherapy in the last 2 weeks, or 6 weeks for specific drugs, and have recovered from any side effects.I haven't taken any experimental drugs in the last 3 weeks.I am on bisphosphonates for high calcium or need RANKL inhibitor treatment.I have or am at risk for an autoimmune disease.I have not had signs of infection in the last 2 weeks.I do not have any unmanaged ongoing illnesses.I have not taken any antibiotics by mouth or IV in the last 2 weeks.My lymphoma has changed into a more aggressive form known as DLBCL.I have a tumor that is larger than 1.5 cm, confirmed by a scan.I am 18 years old or older.My kidneys are working well enough to clear waste.I have been treated with gemcitabine and oxaliplatin before.I have a history of lung scarring or inflammation.I have active tuberculosis.I have not had severe infections in the last 4 weeks.I am not pregnant or breastfeeding.I have a tumor that is larger than 1.5 cm, confirmed by a scan.Your white blood cell count is at least 2,500 cells per microliter, unless your bone marrow is affected by lymphoma.My doctor expects me to live more than 3 months.
- Group 1: Treatment (rituximab, gemcitabine, oxaliplatin, atezolizumab)
- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
What conditions is Atezolizumab employed to address?
"Atezolizumab has been known to effectively address the symptoms of urinary bladder, and can also be used when treating diffuse large b-cell lymphoma (DLBCL), small cell lung cancer (SCLC) or head and neck carcinoma."
Is admission to this trial open at the moment?
"This study has reached its recruitment quota and is no longer accepting patients. Initially posted on March 7, 2018 and last modified November 17, 2022; however, there are currently 2698 trials recruiting lymphoma (large B-cell diffuse) sufferers as well as 1428 studies that require participants for Atezolizumab testing."
To what extent does Atezolizumab pose a risk to individuals?
"Due to its Phase 1 design, the safety profile of Atezolizumab is limited and thus Power assigned it a score of 1."
How many test subjects are actively participating in this investigation?
"Unfortunately, the recruitment period for this research has ended. It was initially posted on March 7th 2018 and concluded with an edit to its page on November 17th 2022. Nevertheless, there are still 2,698 clinical trials seeking participants affected by diffuse large B-cell lymphoma and 1,428 separate studies recruiting patients receiving Atezolizumab as a treatment option."
Has Atezolizumab been examined in any prior experiments?
"Atezolizumab was initially investigated in 1993 at National Institutes of Health Clinical Center, 9000 Rockville Pike. As of now, there are a total 2865 completed trials and 1428 active clinical trials located mainly within the state of Georgia and Sacramento."
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