Low-Dose Radiotherapy for Multiple Myeloma with Bone Pain
Trial Summary
What is the purpose of this trial?
This phase II trial studies how well low-dose radiotherapy works in treating bone pain in patients with multiple myeloma that has spread to the bone. Radiation therapy uses high energy x-rays, gamma rays, neutrons, protons, or other sources to kill tumor cells and shrink tumors. Low-dose radiotherapy may be more convenient for patients and their families, may not interfere as much with the timing of chemotherapy, and may have less chance for short term or long-term side effects from the radiation.
Will I have to stop taking my current medications?
The trial does not specify if you need to stop your current medications, but it allows changes to systemic therapy or use of bisphosphonates (medications that prevent bone loss) for 4 weeks before and after the radiation therapy.
What data supports the effectiveness of the treatment Low-Dose Radiotherapy for Multiple Myeloma with Bone Pain?
Research shows that radiation therapy can provide pain relief for patients with multiple myeloma, with studies indicating that 81% of cases experience pain relief. Additionally, radiation therapy is effective in managing bone pain from metastases, with more than 80% of patients experiencing pain relief.12345
Is low-dose radiotherapy safe for humans?
How does low-dose radiotherapy differ from other treatments for multiple myeloma with bone pain?
Low-dose radiotherapy is unique because it uses smaller doses of radiation to relieve bone pain in multiple myeloma patients, focusing on symptom relief rather than curing the disease. This approach is particularly beneficial for patients with uncomplicated bone lesions, offering effective pain control with potentially fewer side effects compared to higher-dose treatments.1291011
Research Team
Adam Garsa, MD
Principal Investigator
University of Southern California
Eligibility Criteria
This trial is for patients with multiple myeloma and painful bone metastases. Participants must have a pain score of at least 2, confirmed diagnosis, and be able to consent. They can have had any number of prior treatments but should not be pregnant or have received radiation on the index lesion.Inclusion Criteria
Exclusion Criteria
Timeline
Screening
Participants are screened for eligibility to participate in the trial
Radiation
Participants receive low-dose radiation therapy at consecutive business days 1 and 2
Follow-up
Participants are monitored for pain relief and quality of life after radiation therapy
Treatment Details
Interventions
- Low-Dose Radiotherapy
Low-Dose Radiotherapy is already approved in European Union, United States, Canada, Japan, China, Switzerland for the following indications:
- Painful bone metastases from multiple myeloma
- Symptomatic relief of bone pain
- Painful bone metastases from multiple myeloma
- Symptomatic relief of bone pain
- Spinal cord compression
- Painful bone metastases from multiple myeloma
- Symptomatic relief of bone pain
- Painful bone metastases from multiple myeloma
- Symptomatic relief of bone pain
- Painful bone metastases from multiple myeloma
- Symptomatic relief of bone pain
- Painful bone metastases from multiple myeloma
- Symptomatic relief of bone pain
Find a Clinic Near You
Who Is Running the Clinical Trial?
University of Southern California
Lead Sponsor
National Cancer Institute (NCI)
Collaborator