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Exercise Therapy for Cancer

Recruiting at 6 trial locations
NI
LJ
Overseen ByLee Jones, PhD
Age: 18+
Sex: Any
Trial Phase: Phase 1
Sponsor: Memorial Sloan Kettering Cancer Center
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)
Approved in 2 JurisdictionsThis treatment is already approved in other countries

Trial Summary

Do I have to stop taking my current medications for the trial?

The trial information does not specify whether you need to stop taking your current medications. However, you cannot be receiving any form of antitumor therapy to participate.

What data supports the idea that Exercise Therapy for Cancer is an effective treatment?

The available research shows that Exercise Therapy for Cancer is effective in improving the quality of life for cancer patients. It helps reduce side effects like fatigue and depression, which are common during and after cancer treatment. Studies indicate that exercise can be beneficial at any stage of cancer treatment, whether before, during, or after, and it aids in recovery and overall well-being. Compared to other treatments, exercise is unique because it not only helps manage symptoms but also supports long-term health and survival. This makes it a valuable addition to cancer care.12345

What safety data exists for exercise therapy in cancer treatment?

Exercise therapy for cancer patients, including pediatric and adult populations, is generally safe. A nationwide survey in Germany found a very low incidence of adverse events (AEs) during supervised exercise interventions for pediatric cancer patients, with no life-threatening consequences reported. A systematic review and meta-analysis of randomized controlled trials in adult cancer patients also reported exercise therapy as safe, with 44 AEs across 48 trials. Exercise therapy is recommended for cancer patients to improve cardiorespiratory fitness and manage side effects, with safety procedures like regular breaks and medical consultations in place to minimize risks.16789

Is Exercise Therapy a promising treatment for cancer?

Yes, Exercise Therapy is a promising treatment for cancer. It helps improve the quality of life, reduces fatigue, and increases strength and fitness in cancer patients. It is safe and can be tailored to individual needs, making it a valuable part of cancer recovery and management.410111213

What is the purpose of this trial?

The purpose of this study is to find out whether exercise therapy is an effective and safe treatment that causes few or mild side effects when done before standard surgery for solid tumor cancer. The researchers will also study whether the program is feasible (practical) by tracking how well participants follow the program.

Research Team

Exercise Oncology Program: Lee Jones ...

Lee Jones, PhD

Principal Investigator

Memorial Sloan Kettering Cancer Center

Eligibility Criteria

This clinical trial is for individuals with solid tumor cancers who are scheduled to undergo standard surgery. The study aims to evaluate the effectiveness and safety of exercise therapy prior to surgery.

Inclusion Criteria

Non-exercisers, defined as ≤60 minutes of moderate or vigorous exercise/week based on self-report using a validated survey
I have a confirmed, operable cancer that has not been treated yet.
My surgery is scheduled at least 3 weeks from now and won't be delayed for exercise therapy.
See 4 more

Exclusion Criteria

My cancer has spread to distant parts of my body.
I am currently undergoing treatment for cancer.
Any other condition (e.g., pregnancy) or intercurrent illness that, in the opinion of the investigator, makes the subject a poor candidate for study participation
See 2 more

Timeline

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Exercise Therapy

Participants undergo individualized treadmill walking up to 5 times weekly to achieve a cumulative dose of 225 minutes per week, administered via a decentralized platform

3 weeks
Remote monitoring via DPEx platform

Follow-up

Participants are monitored for safety and effectiveness after exercise therapy

4 weeks

Treatment Details

Interventions

  • Exercise Therapy
Trial Overview The intervention being studied is exercise therapy. Researchers want to see if it's an effective pre-surgery treatment for those with solid tumors, and they'll also check how practical it is by monitoring participants' adherence.
Participant Groups
1Treatment groups
Experimental Treatment
Group I: Exercise therapyExperimental Treatment1 Intervention
Exercise therapy will comprise individualized treadmill walking delivered up to 5 times weekly (over a 7-day period) to achieve a weekly cumulative dose of 225 minutes per week. The minimum treatment period will be 3 weeks. Exercise therapy will be administered via a patient-centric, decentralized platform: Digital Platform for Exercise (DPEx). DPEx will permit all study procedures to be conducted remotely in patients' homes.

Exercise Therapy is already approved in United States, European Union for the following indications:

🇺🇸
Approved in United States as Exercise Therapy for:
  • Improvement of cardiorespiratory fitness in men with low-risk prostate cancer on active surveillance
  • Reduction of urinary obstruction/irritation and fear of recurrence in men with low-risk prostate cancer on active surveillance
🇪🇺
Approved in European Union as Exercise Therapy for:
  • General health and wellness
  • Prevention of chronic diseases through physical activity

Find a Clinic Near You

Who Is Running the Clinical Trial?

Memorial Sloan Kettering Cancer Center

Lead Sponsor

Trials
1,998
Recruited
602,000+

Findings from Research

Physical activity and targeted exercise therapy can significantly improve outcomes for cancer patients, helping to manage side effects like fatigue and depression, especially when introduced right after diagnosis.
Moderate endurance training combined with individualized strength training is particularly effective and can be recommended for all cancer patients, regardless of cancer type, while ensuring contraindications are considered.
[Physical activity and exercise therapy in oncology].Zoth, N., Böhlke, L., Theurich, S., et al.[2023]
A study of 350 cancer patients receiving physical therapist-led exercise counseling showed significant reductions in global distress and fatigue, indicating that exercise counseling can effectively improve symptoms related to cancer treatment.
Patients reported notable improvements in overall health and well-being after counseling, suggesting that exercise may play a crucial role in enhancing quality of life for cancer patients.
Physical Therapist-Led Exercise Assessment and Counseling in Integrative Cancer Care: Effects on Patient Self-reported Symptoms and Quality of Life.Lopez, G., Eddy, C., Liu, W., et al.[2023]
Exercise is an effective therapeutic intervention for cancer patients, helping to reduce side effects from treatments and significantly improving their quality of life during and after treatment.
Engaging in exercise before, during, and after cancer treatments leads to numerous beneficial outcomes, making it a crucial part of care for both patients undergoing treatment and survivors.
Exercise Recommendations for Cancer-Related Fatigue, Cognitive Impairment, Sleep problems, Depression, Pain, Anxiety, and Physical Dysfunction: A Review.Mustian, KM., Sprod, LK., Janelsins, M., et al.[2021]

References

[Physical activity and exercise therapy in oncology]. [2023]
Physical Therapist-Led Exercise Assessment and Counseling in Integrative Cancer Care: Effects on Patient Self-reported Symptoms and Quality of Life. [2023]
Exercise Recommendations for Cancer-Related Fatigue, Cognitive Impairment, Sleep problems, Depression, Pain, Anxiety, and Physical Dysfunction: A Review. [2021]
4.Czech Republicpubmed.ncbi.nlm.nih.gov
[Intervention Exercise Program for Cancer Patients with Breast Cancer]. [2019]
Exercise in cancer. [2021]
Adverse Events During Supervised Exercise Interventions in Pediatric Oncology-A Nationwide Survey. [2021]
Exercise Therapy and Radiation Therapy for Cancer: A Systematic Review. [2021]
Efficacy of Exercise Therapy on Cardiorespiratory Fitness in Patients With Cancer: A Systematic Review and Meta-Analysis. [2022]
Exercise Training for Cancer Survivors. [2021]
10.United Statespubmed.ncbi.nlm.nih.gov
A model program: exercise intervention for cancer rehabilitation. [2017]
11.United Statespubmed.ncbi.nlm.nih.gov
Exercise therapy across the lung cancer continuum. [2021]
12.United Statespubmed.ncbi.nlm.nih.gov
Maximal exercise testing of men with prostate cancer being treated with androgen deprivation therapy. [2014]
Supervised physical exercise to improve the quality of life of cancer patients: the EFICANCER randomised controlled trial. [2018]
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