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Resistance training for Colon Cancer (FORCE Trial)

N/A
Waitlist Available
Led By Bette J Caan, DrPH
Research Sponsored by Kaiser Permanente
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 3-6 months
Awards & highlights

FORCE Trial Summary

This trial is testing whether a resistance training intervention can help stage II and III colon cancer patients undergoing chemotherapy by reducing chemotherapy-related toxicity and improving muscle mass and specific inflammatory markers.

Eligible Conditions
  • Colon Cancer
  • Resistance Training
  • Chemotherapy Side Effects

FORCE Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~3-6 months
This trial's timeline: 3 weeks for screening, Varies for treatment, and 3-6 months for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Number of moderate and severe chemotherapy-associated toxicities
Relative dose intensity (RDI)

FORCE Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: Resistance training groupExperimental Treatment1 Intervention
Participants randomized to the resistance training (RT) group will receive an in-person and telephone-based intervention to promote home-based resistance training. The exercise intervention will begin by the 3rd adjuvant chemotherapy visit and continue exercise through the completion of post-operative chemotherapy. Participants will work with an exercise professional with expertise working with oncology patients.
Group II: Usual care groupActive Control1 Intervention
Participants randomized to the usual care (U) group will be instructed to refer to their physician regarding what forms of exercise are safe for them, given their medical history. The U group will be told to continue whatever exercise program they have been undertaking up to enrolling in the study, but not to increase exercise or begin weight-lifting over the period of study participation.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Resistance training
2008
Completed Phase 3
~1010

Find a Location

Who is running the clinical trial?

Dana-Farber Cancer InstituteOTHER
1,079 Previous Clinical Trials
340,765 Total Patients Enrolled
Penn State UniversityOTHER
355 Previous Clinical Trials
125,574 Total Patients Enrolled
Kaiser PermanenteLead Sponsor
538 Previous Clinical Trials
24,113,605 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
clinicaltrials.govStudy
FOcus on Reducing Dose-limiting Toxicities in Colon Cancer With Resistance Exercise Study
2018. "FOcus on Reducing Dose-limiting Toxicities in Colon Cancer With Resistance Exercise Study". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT03291951.
~26 spots leftby Apr 2025
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