Cognitive-Behavioral Treatment for PTSD-Related Nightmares in Veterans
Trial Summary
Will I have to stop taking my current medications?
The trial requires that you be stable on any psychoactive medications for at least two weeks before starting. This means you can continue your current medications as long as they have been stable for that period.
What data supports the effectiveness of the treatment Exposure, Relaxation, and Rescripting Therapy (ERRT) for PTSD-related nightmares in Veterans?
Research shows that ERRT, adapted for military use, has been effective in reducing nightmare frequency and severity, improving sleep quality, and decreasing symptoms of PTSD and depression in Veterans. In a pilot study, 50% of participants reported no nightmares a week after treatment, and these improvements were maintained at a 2-month follow-up.12345
Is cognitive-behavioral treatment for PTSD-related nightmares in veterans safe?
The studies on Exposure, Relaxation, and Rescripting Therapy (ERRT) for trauma-related nightmares in veterans and military personnel suggest that it is generally safe. Participants reported improvements in sleep quality and a reduction in nightmares, with no significant safety concerns mentioned.12456
How is the treatment ERRT different from other treatments for PTSD-related nightmares in veterans?
ERRT (Exposure, Relaxation, and Rescripting Therapy) is unique because it combines exposure techniques with relaxation and rescripting strategies to directly target and reduce the frequency and severity of nightmares, improve sleep quality, and alleviate PTSD symptoms in veterans. This approach is specifically adapted for military populations and focuses on modifying the content of nightmares, which is different from other treatments that may not directly address the nightmares themselves.12347
What is the purpose of this trial?
Trauma-related nightmares in Veterans are associated with poor clinical outcomes, greater substance use, and increased risk of suicide. In spite of an urgent need to reduce the burden of trauma-related nightmares, the underlying physiological changes associated with them are poorly understood, and there are no clear evidence-based recommendations for their treatment. Limitations of current assessment procedures represent a barrier to improved care. In-laboratory sleep studies rarely capture nightmares, limiting the knowledge about them and their response to treatment. This study addresses these limitations by using extended, in-home sleep monitoring to capture sleep data associated with nightmare reports in Veterans, and assessing how these features are altered throughout a cognitive-behavioral nightmare treatment. Results from this study will increase understanding of trauma-related nightmares, and advance strategies for personalizing symptom management for Veterans.
Research Team
Katherine Elizabeth Miller, PhD
Principal Investigator
Minneapolis VA Health Care System, Minneapolis, MN
Eligibility Criteria
This trial is for Veterans with PTSD or subthreshold PTSD, experiencing frequent trauma-related nightmares, and enrolled in VA care at the Minneapolis VA Health Care System. They must have stable housing, be on steady psychoactive meds for two weeks prior to the study, and not be involved in other PTSD-focused treatments.Inclusion Criteria
Exclusion Criteria
Timeline
Screening
Participants are screened for eligibility to participate in the trial
Baseline Sleep Monitoring
Participants monitor their sleep for a week using a multi-night mattress actigraphy and one-night polysomnography to calibrate sleep efficiency and identify untreated sleep apnea.
Treatment
Participants undergo five weeks of either Exposure, Relaxation, and Rescripting Therapy (ERRT) or Sleep and Nightmare Management, with continuous sleep monitoring.
Post-treatment Assessment
Assessment of subjective symptom change and physiological parameters post-treatment.
Follow-up
Participants are monitored for changes in sleep and nightmare-related symptoms at 1-week and 3-month post-treatment.
Treatment Details
Interventions
- Exposure, Relaxation, and Rescripting Therapy
- Sleep and Nightmare Management
Exposure, Relaxation, and Rescripting Therapy is already approved in United States, European Union for the following indications:
- Trauma-related nightmares
- Sleep disturbances
- PTSD symptoms
- Depression symptoms
- Trauma-related nightmares
- Sleep disturbances
- PTSD symptoms
- Depression symptoms
Find a Clinic Near You
Who Is Running the Clinical Trial?
VA Office of Research and Development
Lead Sponsor