Ommaya Reservoir for Brain Cancer
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial explores a new method for monitoring brain tumors using a small device called an Ommaya reservoir, placed under the scalp during a biopsy. The reservoir enables doctors to collect cerebrospinal fluid (CSF) samples over time without repeated spinal taps. By analyzing these samples, researchers aim to identify biomarkers that indicate tumor status and treatment response. This trial may suit individuals with a suspected or diagnosed brain tumor who plan to undergo a biopsy at the Mayo Clinic and are willing to provide CSF samples in the future. As an unphased trial, this study offers a unique opportunity to contribute to innovative research that could enhance future brain tumor monitoring techniques.
Will I have to stop taking my current medications?
The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.
What prior data suggests that the Ommaya reservoir placement is safe for collecting biomarkers in brain tumor patients?
Research has shown that placing an Ommaya reservoir is generally safe, though some risks exist. In a study of 501 placements, about 8% of patients developed infections related to the reservoir. These infections were serious, including conditions like meningitis (swelling around the brain and spinal cord) or cellulitis (a skin infection).
Other studies highlight the importance of precise reservoir placement to avoid complications. When done correctly, this procedure allows doctors to easily collect fluid around the brain and spine without repeated spinal taps.
Overall, while there is a small risk of infection, Ommaya reservoirs serve as a valuable tool for ongoing monitoring in patients with brain tumors.12345Why are researchers excited about this trial?
Researchers are excited about the use of Ommaya reservoirs in brain tumor patients because this method allows for the direct collection of cerebrospinal fluid (CSF) over time. Unlike traditional biopsies that provide only a single snapshot of the tumor, the Ommaya reservoir enables continuous monitoring of biomarkers, offering a dynamic view of tumor changes and treatment responses. This could lead to more personalized treatment strategies, adapting therapies based on real-time data rather than relying solely on static, initial biopsy results.
What evidence suggests that the Ommaya reservoir is effective for collecting biomarkers in brain tumor patients?
Research has shown that the Ommaya reservoir is a useful tool for accessing cerebrospinal fluid (CSF) in the brain. This device allows doctors to collect CSF samples multiple times without performing a spinal tap. In this trial, participants will have an Ommaya reservoir placed during a standard of care biopsy. Studies have found that using the Ommaya reservoir, along with treatments like fluid removal and targeted radiation, helps control brain tumors in about 81.2% of cases. It is often used in brain cancer treatment to deliver medicine directly to the brain and to frequently check the CSF for monitoring conditions. This makes it a promising tool for tracking brain tumor growth and assessing treatment effectiveness over time.12678
Who Is on the Research Team?
Terry C. Burns, M.D., Ph.D.
Principal Investigator
Mayo Clinic in Rochester
Are You a Good Fit for This Trial?
Inclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Ommaya Reservoir Placement
Patients undergo Ommaya reservoir placement during standard of care biopsy for longitudinal biomarker collection
Biomarker Collection
Longitudinal collection of cerebrospinal fluid (CSF) samples using the Ommaya reservoir
Follow-up
Participants are monitored for safety and effectiveness of biomarker collection
What Are the Treatments Tested in This Trial?
Interventions
- Ommaya Reservoir Placement
How Is the Trial Designed?
1
Treatment groups
Experimental Treatment
Patients undergo Ommaya reservoir placement during standard of care biopsy. Patients then undergo extraction of CSF while on study. Patients may also optionally undergo lumbar puncture while on study. Patients also undergo CT or MRI on study.
Find a Clinic Near You
Who Is Running the Clinical Trial?
Mayo Clinic
Lead Sponsor
National Institute of Neurological Disorders and Stroke (NINDS)
Collaborator
Citations
Ommaya Reservoir - StatPearls - NCBI Bookshelf
This device provides direct access to the cerebrospinal fluid (CSF), enabling repeated intraventricular drug administration—such as chemotherapy ...
Stereotactic aspiration alone or Ommaya placement and ...
Results. Overall rate of tumor control for combined treatment of Ommaya placement plus aspiration plus SRS was 81.2% (62.5–99.9%, p < 0.001) ...
Ommaya Reservoir Placement for Brain Tumor Biomarker ...
The purpose of this study is to determine the safety and feasibility of intra-operative Ommaya Reservoir placement during a clinically indicated operation ...
Ommaya Reservoir Placement for Brain Tumor Biomarker ...
The purpose of this study is to determine the safety and feasibility of intra-operative Ommaya Reservoir placement during a clinically indicated operation for ...
Image guidance for the placement of Ommaya reservoirs
The Ommaya reservoir is used widely in neuro-oncology, primarily for the instillation of intrathecal chemotherapy and frequent CSF sampling in patients with CNS ...
Ommaya reservoir-related infections: Clinical ...
Among 501 OR placements, 40 patients (8%) developed an ORRI. These presented with meningitis and/or meningoencephalitis (60%), cellulitis (20%), ...
7.
healthy.kaiserpermanente.org
healthy.kaiserpermanente.org/health-wellness/health-encyclopedia/he.ommaya-reservoir-care-instructions.abr0703Ommaya Reservoir: Care Instructions
An Ommaya (say "oh-MY-uh") reservoir is a small, soft, dome-shaped container. It is placed under your scalp. It has a thin tube called a catheter attached to it ...
Safe Placement of Ommaya Reservoirs in ...
The purpose of this study was to assess the risk of hemorrhagic complications in thrombocytopenic patients after Ommaya reservoir placement.
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