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Non-invasive Brain Stimulation
HD-tDCS for Primary Progressive Aphasia
N/A
Waitlist Available
Led By Elias Granadillo
Research Sponsored by Medical College of Wisconsin
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 2 weeks
Awards & highlights
Study Summary
This trial is testing a new therapy, HD-tDCS, to see if it can help improve language skills in people with Primary Progressive Aphasia.
Eligible Conditions
- Primary Progressive Aphasia
Timeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ 2 weeks
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~2 weeks
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Primary outcome measures
Language Performance on seven cognitive assessments: Picture Naming, Letter & Category Fluency, Digit Span Test, Phonological Short-term Memory Test, Word and non-word rhyme matching, Spontaneous Speech Sample, and Communicative Effectiveness Index.
Secondary outcome measures
Brain Chemistry
Neuronal Frequencies and Synchronizations as seen on rsMEG (resting state MEG)
Trial Design
2Treatment groups
Experimental Treatment
Group I: Sham, then HD-tDCSExperimental Treatment2 Interventions
Subjects receive Sham sessions (no electric current) once a day (QD) for a total of 10 sessions over 2 weeks (Monday-Friday). After a washout period of 16 weeks, subjects receive High Dose transcranial Direct Current Stimulation (HD-tDCS) lasting 20 minutes at an electric current intensity of up to 2mA in the left posterior temporo-parietal cortex (TPC). Stimulation sessions are delivered once a day (QD) for a total of 10 sessions over 2 weeks (Monday-Friday).
Group II: HD-tDCS, then ShamExperimental Treatment2 Interventions
Subjects receive High Dose transcranial Direct Current Stimulation (HD-tDCS) lasting 20 minutes at an electric current intensity of up to 2mA in the left posterior temporo-parietal cortex (TPC). Stimulation sessions are delivered once a day (QD) for a total of 10 sessions over 2 weeks (Monday-Friday). After a washout period of 16 weeks, subjects receive Sham sessions (no electric current) once a day (QD) for a total of 10 sessions over 2 weeks (Monday-Friday).
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
HD-tDCS
2021
Completed Early Phase 1
~50
Sham
2013
Completed Phase 3
~2060
Find a Location
Who is running the clinical trial?
Medical College of WisconsinLead Sponsor
609 Previous Clinical Trials
1,162,563 Total Patients Enrolled
Elias GranadilloPrincipal InvestigatorThe Medical College of Wisconsin
Frequently Asked Questions
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Are there any vacancies remaining in this research project?
"According to clinicaltrials.gov, the medical investigation in question is not currently actively enrolling patients. Initially published on February 24th 2020 and last edited August 26th 2022, this trial has yet to begin recruiting participants; however, 119 other trials are looking for new subjects right now."
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