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Immunosuppressant

Tacrolimus for Kidney Failure (EVOKE-RT Trial)

Phase 4
Waitlist Available
Led By Thomas McCune, MD
Research Sponsored by Sentara Norfolk General Hospital
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 6 months
Awards & highlights

EVOKE-RT Trial Summary

This trial looked at how well different doses of tacrolimus work in kidney transplant patients.

Eligible Conditions
  • Kidney Failure, Kidney Transplant

EVOKE-RT Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~6 months
This trial's timeline: 3 weeks for screening, Varies for treatment, and 6 months for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
I. Percentage of tacrolimus levels in range after transplantation
Secondary outcome measures
II. Time in therapeutic range for tacrolimus trough levels during intervals after transplantation based on the Rosendaal Method

EVOKE-RT Trial Design

2Treatment groups
Active Control
Group I: EnvarsusActive Control1 Intervention
Once-daily extended-release tacrolimus
Group II: PrografActive Control1 Intervention
twice-daily tacrolimus

Find a Location

Who is running the clinical trial?

Veloxis PharmaceuticalsIndustry Sponsor
41 Previous Clinical Trials
3,100 Total Patients Enrolled
9 Trials studying Kidney Failure
1,154 Patients Enrolled for Kidney Failure
Sentara Norfolk General HospitalLead Sponsor
11 Previous Clinical Trials
881 Total Patients Enrolled
Thomas McCune, MDPrincipal InvestigatorSentara Norfolk General Hospital

Media Library

Tacrolimus (Immunosuppressant) Clinical Trial Eligibility Overview. Trial Name: NCT03760263 — Phase 4
Kidney Failure Research Study Groups: Envarsus, Prograf
Kidney Failure Clinical Trial 2023: Tacrolimus Highlights & Side Effects. Trial Name: NCT03760263 — Phase 4
Tacrolimus (Immunosuppressant) 2023 Treatment Timeline for Medical Study. Trial Name: NCT03760263 — Phase 4

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is enrollment still open for this research project?

"Affirmative, the latest information on clinicaltrials.gov reveals that this research is actively looking for participants to join in. The trial was initially made available on January 16th 2020 and has been recently updated November 7th 2022; 54 patients are being sought from a single location."

Answered by AI

Are any other investigations underway that involve Envarsus?

"At present, there are 18 Phase 3 trials and 150 active clinical studies researching Envarsus. Nashville, Tennessee is the hub for this research with 871 locations running related experiments."

Answered by AI

How many participants can join this research project?

"Aye, the latest update on clinicaltrials.gov affirms that this medical trial is still recruiting subjects. It was first opened to enrolment back in January 16th 2020 and has been recently refreshed November 7th 2022. Thus far, 54 participants have joined from a single location."

Answered by AI

What medical conditions can Envarsus be employed to address?

"Envarsus is a commonly-used treatment for atopic dermatitis, as well as rejection of liver and kidney transplants, and psoriasis."

Answered by AI

What potential health risks accompany Envarsus usage?

"The security of Envarsus has been preliminarily established, thus it is given a rating of 3 on the scale. This reflects the fact that this drug has already received approval to enter Phase 4 trials."

Answered by AI

Who meets the criteria to participate in this clinical research?

"This clinical trial needs to recruit 54 volunteers, aged between 18 and 70 years old, who have been diagnosed with renal failure. For eligibility into this research study, participants must be able to attend Sentara Norfolk General Hospital for a kidney transplant."

Answered by AI

Are participants aged below 85 allowed to join this research trial?

"This clinical trial requires participants to be between 18 and 70 years old. There are separate trials for those younger than 18, with 52 studies accessible, as well as 277 other options available for patients over 65."

Answered by AI
~9 spots leftby Apr 2025