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Alpha-2 Agonist

Dexmedetomidine for Chronic Pain

Phase 4
Waitlist Available
Led By Lisa Doan, MD
Research Sponsored by NYU Langone Health
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 48 hours post-surgery (day 2)
Awards & highlights

Study Summary

This trial is looking at whether dexmedetomidine, given during surgery, can reduce pain in patients undergoing lumbar spinal fusion surgery. One hundred ten subjects will be enrolled and followed for six weeks post-op.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~48 hours post-surgery (day 2)
This trial's timeline: 3 weeks for screening, Varies for treatment, and 48 hours post-surgery (day 2) for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Morphine Equivalents Used During the First 48 Hours Post-Surgery
Secondary outcome measures
Length of Hospital Stay
Length of PACU Stay
Mean Numeric Pain Rating Scale (NRS) Scores During the First 48 Hours Post-Surgery
+8 more

Side effects data

From 2020 Phase 4 trial • 798 Patients • NCT02004613
57%
Clinically important hypotension
9%
Clinically important bradycardia
1%
infection
1%
stroke
1%
Atelectasis
1%
Hemorrhage
100%
80%
60%
40%
20%
0%
Study treatment Arm
Placebo
Dexmedetomidine

Trial Design

2Treatment groups
Experimental Treatment
Placebo Group
Group I: IV dexmedetomidineExperimental Treatment1 Intervention
Dexmedetomidine is an alpha-2-adrenergic agonist. It is commonly used for sedation and as an adjunct to general anesthetics.
Group II: PlaceboPlacebo Group1 Intervention
saline placebo
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Dexmedetomidine
FDA approved

Find a Location

Who is running the clinical trial?

NYU Langone HealthLead Sponsor
1,367 Previous Clinical Trials
839,678 Total Patients Enrolled
5 Trials studying Chronic Pain
4,382 Patients Enrolled for Chronic Pain
Lisa Doan, MDPrincipal InvestigatorNYU Langone Health
5 Previous Clinical Trials
912 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
clinicaltrials.govStudy
Study on the Effects of Intravenous Dexmedetomidine on Pain in Patients Undergoing Elective Spinal Surgery
2016. "Study on the Effects of Intravenous Dexmedetomidine on Pain in Patients Undergoing Elective Spinal Surgery". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT03325972.
~10 spots leftby Apr 2025
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