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Allergy Immunotherapy

Sublingual allergy immunotherapy tablet for Allergic Rhinitis (MATIC Trial)

Phase 3
Waitlist Available
Led By Antje Schuster, MD
Research Sponsored by ALK-Abelló A/S
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be younger than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up the last 8 weeks of approximately 12 months of treatment
Awards & highlights

MATIC Trial Summary

This trial is testing whether house dust mite tablets are better than a placebo at reducing allergy symptoms in children aged 5-11.

Eligible Conditions
  • Allergic Rhinitis due to House Dust Mite
  • Dust Mite Allergy

MATIC Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~the last 8 weeks of approximately 12 months of treatment
This trial's timeline: 3 weeks for screening, Varies for treatment, and the last 8 weeks of approximately 12 months of treatment for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Pharmaceutical Preparations
Secondary outcome measures
Combined rhinoconjunctivitis symptoms and medication use
Rhinitis medication
Rhinitis symptoms
+1 more

MATIC Trial Design

2Treatment groups
Experimental Treatment
Placebo Group
Group I: Active treatmentExperimental Treatment1 Intervention
HDM SLIT-tablet plus allergy and asthma rescue medication
Group II: PlaceboPlacebo Group1 Intervention
Placebo oral tablet plus allergy and asthma rescue medication

Find a Location

Who is running the clinical trial?

ALK-Abelló A/SLead Sponsor
76 Previous Clinical Trials
326,846 Total Patients Enrolled
Antje Schuster, MDPrincipal InvestigatorProfessor of Pediatrics, Düsseldorf University Hospital

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

How many individuals are involved in this research project?

"This study is no longer recruiting patients. The listing for the clinical trial was first posted on October 12th, 2019 and edited for the last time on May 23rd, 2022. There are other active studies; as of right now, there 67 trials concerning allergic rhinitis and 2 more specifically for Sublingual allergy immunotherapy tablet admitting patients."

Answered by AI

Are there any similar drugs that have undergone testing like Sublingual allergy immunotherapy tablet?

"There are two ongoing Phase 3 clinical trials for the Sublingual allergy immunotherapy tablet. Although most of the 145 live studies for this medication are based in Oklahoma City, Oklahoma, there is significant geographical diversity."

Answered by AI

Has the Sublingual allergy immunotherapy tablet received FDA approval?

"Sublingual allergy immunotherapy tablet is rated a 3 for safety by our team at Power. This is because it has reached Phase 3 in clinical trials, meaning that there is both efficacy and safety data supporting its use."

Answered by AI

If a potential patient is 35 years old or younger, can they be included in this research project?

"Children aged 5 to 11 can be enrolled in this clinical trial, as seen in the inclusion criteria. Out of the 72 total studies, 26 are for patients under 18 years old and 46 are for those over 65."

Answered by AI

Are we currently able to enroll new patients in this trial?

"This study is not currently recruiting patients. However, if you're looking for other studies to participate in, there are 67 trials for allergic rhinitis and 2 Sublingual allergy immunotherapy tablet clinical trials that are actively enrolling participants."

Answered by AI

Have patients undergone this type of treatment before as part of a clinical trial?

"Currently, there are 2 ongoing studies for Sublingual allergy immunotherapy tablet in 46 cities and 13 countries. The first clinical trial was conducted in 2018 and completed Phase 3 drug approval stages. ALK-Abelló A/S sponsored the study which enrolled 600 patients. Since then, 18293 similar trials have been run."

Answered by AI

Are there a lot of research centers conducting this clinical trial in Canada?

"63 total sites are currently participating in this trial, with locations including North York, Marietta and Miami. If you are considering joining the trial, it may be helpful to select a site near you in order to reduce travel requirements."

Answered by AI

How do I sign up for this opportunity to test a new medication?

"1459 children between the ages of 5 and 11 who struggle with allergic rhinitis are being recruited for this study. The most important candidate requirements are as follows: they must have had AR symptoms on 8 or more days in the 2 weeks leading up to the start of the study, be either male or female, have a history of HDM AR/C (with or without asthma), and still experience allergic rhinitis symptoms even after receiving allergy medication in the year prior to screening."

Answered by AI

Who else is applying?

How old are they?
18 - 65
What portion of applicants met pre-screening criteria?
Did not meet criteria
What state do they live in?
Ohio
How many prior treatments have patients received?
3+

Why did patients apply to this trial?

I’ve been suffering from rhinitis for my whole life. Hoping this will help.
PatientReceived 1 prior treatment
~265 spots leftby May 2025