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Heme Synthesis Inhibitor

Panhematin for Acute Porphyrias

Phase 2
Waitlist Available
Led By Karl E Anderson, MD
Research Sponsored by The University of Texas Medical Branch, Galveston
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 4 days
Awards & highlights

Study Summary

This trial will test the effectiveness and safety of hemin for treating acute attacks of porphyria. Two groups will receive either hemin plus glucose or a placebo plus glucose, and treatment will be given as soon as possible after symptoms appear.

Eligible Conditions
  • Acute Porphyrias

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~4 days
This trial's timeline: 3 weeks for screening, Varies for treatment, and 4 days for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Pain scale
Secondary outcome measures
Biochemical effects of Panhematin
Other outcome measures
Panhematin
Effects of genetic features on response to Panhematin
Use of reconstitution of Panhematin with albumin

Trial Design

2Treatment groups
Experimental Treatment
Placebo Group
Group I: PanhematinExperimental Treatment2 Interventions
Panhematin plus glucose
Group II: PlaceboPlacebo Group1 Intervention
Placebo (saline) plus glucose
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Dextrose, unspecified form
FDA approved

Find a Location

Who is running the clinical trial?

The University of Texas Medical Branch, GalvestonLead Sponsor
241 Previous Clinical Trials
56,573 Total Patients Enrolled
Karl E Anderson, MDPrincipal InvestigatorUT, Galveston
2 Previous Clinical Trials
68 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is it feasible to become a participant in this research trial?

"Candidates between 18 and 100 years of age who have been diagnosed with porphyria, acute intermittent can apply for this study. The total number of enrollees allowed is 40 individuals."

Answered by AI

What risks might patients encounter when prescribed Panhematin?

"Due to the limited data available on efficacy, Panhematin was given a rating of 2 in terms of safety. This means that while some existing clinical evidence suggests it is safe, more proof-of-concept research is needed before definitive conclusions can be drawn."

Answered by AI

Are there any remaining slots for participants in this clinical experiment?

"At this juncture, this clinical trial is not enrolling participants. It was first published on April 28th 2014 and last edited on July 27th 2021. For those seeking alternative studies, there are currently 2 medical trials for porphyria acute intermittent and 9 for Panhematin actively recruiting patients."

Answered by AI

Is this an original clinical trial?

"Currently, there are nine active trials for Panhematin in 28 countries across 148 cities. Baxter Healthcare Corporation first initiated a trial in 2007 involving 4640 participants which ultimately reached Phase 4 of drug approval. Subsequent to that initial endeavour, 116 additional trails have been completed."

Answered by AI

Has there been past research conducted utilizing Panhematin?

"At present, there are nine active trials exploring the effects of Panhematin with three in Phase 3. While most experiments involving this drug occur in Edmonton, Alberta, it is also being tested at 219 separate locations across the country."

Answered by AI

What is the limit of participants for this investigation?

"At this juncture, no new applicants are being sought for the clinical trial posted on April 28th 2014 and last updated July 27th 2021. However, if you're searching for similar studies, there are currently two trials with open enrollment related to porphyria acute intermittent and nine trials involving Panhematin that have active participant recruitment."

Answered by AI

What medical conditions does Panhematin usually address?

"Panhematin can provide a beneficial cardiac inotropic effect, promote regular menstruation cycles, and facilitate the collection of blood samples."

Answered by AI

Does the study encompass minors or just adults?

"According to the criteria for enrollment in this trial, participants must be between 18 and 100 years of age."

Answered by AI
~2 spots leftby Apr 2025