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Chemotherapy + Bevacizumab for Metastatic Colorectal Cancer (SCOTI Trial)
SCOTI Trial Summary
This trial evaluates the effectiveness of two treatments for late-line mCRC, using a combination of oxaliplatin, irinotecan and bevacizumab.
SCOTI Trial Timeline
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.SCOTI Trial Design
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Who is running the clinical trial?
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- I have previously taken the medication TAS-102.I need treatment for cancer that has spread to my brain and is causing symptoms.I couldn't handle irinotecan before because it caused severe diarrhea.I am 18 years old or older.I can take pills by mouth.I have side effects from previous treatments that are moderate or worse.My cancer's RAS mutation and MMR status are known or can be tested.I have severe nerve damage in my hands or feet.I currently have a fever over 38°C due to an infection.I have not had major surgery in the last 4 weeks.I've had a severe allergic reaction to oxaliplatin or irinotecan.My stage IV colon cancer has worsened despite treatment with standard therapies.My cancer can be measured by tests.I am fully active or can carry out light work.I haven't had any cancer except for non-melanoma skin cancer or non-invasive cancer in the last 3 years.My organs are functioning well.I haven't had cancer treatment in the last 2 weeks.My cancer returned within 6 months after finishing chemotherapy.I had to stop standard treatment due to severe side effects.
- Group 1: Tolerability of TAS-102, oxaliplatin, irinotecan with bevacizumab
- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
In what number of healthcare facilities is this research being conducted?
"At present, this medical study has 7 recruitment sites. These are located in Jersey City, Lakewood and Livingston plus four other locations. To reduce travel costs associated with the trial it is advisable to select a clinic nearby your home address."
What are the associated risks of combining TAS-102, oxaliplatin, irinotecan and bevacizumab for medical purposes?
"There is some evidence suggesting the tolerability of TAS-102, oxaliplatin, irinotecan with bevacizumab; however, there are no data supporting efficacy. Thusly, it recieved a rating of 2 on our safety scale."
Are there any vacancies for participants in this medical research?
"As confirmed on clinicaltrials.gov, this medical study is no longer enrolling patients; it was first posted on May 1st 2023 and had its last update on April 7th 2023. However, 1175 other studies are still open for registration at the moment."
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