Descartes 08 for Multiple Myeloma

Phase-Based Estimates
1
Effectiveness
2
Safety
Sarah Cannon Research Institute at Tennessee Oncology, Nashville, TN
Multiple Myeloma+2 More
Descartes 08 - Biological
Eligibility
18+
All Sexes
Eligible conditions
Multiple Myeloma

Study Summary

This study is evaluating whether a new treatment for myeloma may help patients with myeloma.

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Eligible Conditions

  • Multiple Myeloma
  • Neoplasms, Plasma Cell
  • Multiple Myeloma (MM)

Treatment Effectiveness

Effectiveness Estimate

1 of 3

Compared to trials

Study Objectives

This trial is evaluating whether Descartes 08 will improve 1 primary outcome in patients with Multiple Myeloma. Measurement will happen over the course of 2 years.

2 years
Rate of stringent complete response

Trial Safety

Safety Estimate

2 of 3
This is better than 68% of similar trials

Compared to trials

Trial Design

2 Treatment Groups

Control
Descartes 08

This trial requires 30 total participants across 2 different treatment groups

This trial involves 2 different treatments. Descartes 08 is the primary treatment being studied. Participants will all receive the same treatment. There is no placebo group. The treatments being tested are in Phase 2 and have already been tested with other people.

Descartes 08
Biological
ControlNo treatment in the control group

Trial Logistics

Trial Timeline

Approximate Timeline
Screening: ~3 weeks
Treatment: Varies
Reporting: 2 years
This trial has the following approximate timeline: 3 weeks for initial screening, variable treatment timelines, and roughly 2 years for reporting.

Closest Location

Sarah Cannon Research Institute at Tennessee Oncology - Nashville, TN

Eligibility Criteria

This trial is for patients born any sex aged 18 and older. There are 2 eligibility criteria to participate in this trial as listed below.

Mark “yes” if the following statements are true for you:
High-risk multiple myeloma patients who complete pre-transplant induction treatment anti- myeloma drug combination (minimum 2 drugs).
Patients must be 18 years of age or older at the time of enrollment

Patient Q&A Section

Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What causes multiple myeloma?

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Findings from a recent study highlights a number of risk factors which may have a role in the development of multiple myeloma. Smoking is a significant environmental risk factor for the development of multiple myeloma.

Unverified Answer

Can multiple myeloma be cured?

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The [S]cenario described represents a plausible case of cure. This scenario is not necessarily possible, and this scenario should be considered separately from the general scenario. In particular, the [S]cenario is possible when all clinical and biopsy elements agree and there is no evidence for disease progression for at least 4 months. This scenario has been tested in several patients and has been found to have a high incidence of cure (60% to 96% of patients.) This cure could have important implications for patient management and treatment.

Unverified Answer

How many people get multiple myeloma a year in the United States?

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According to NCI estimates, between 50,000 and 200,000 patients would be diagnosed with MM in 2016, representing 15-28% of all new cancer cases in the United States.

Unverified Answer

What are the signs of multiple myeloma?

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Mucositis and weight loss are the earliest clinical signs or symptoms of myeloma. Pain and night sweats are the main clinical signs when myeloma is present. Lhermitte's sign is another clinical symptom of myeloma. Symptoms such as lethargy, and neurological deficits occur when myeloma progresses to anaemia and/or myeloma bone disease. Osmotic fragility is indicative of myeloma.

Unverified Answer

What is multiple myeloma?

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The incidence of MM has risen in recent years and the most common sites for MM are the spine and bone. The most common age at diagnosis for patients with MM is 66. The number of patients with MM in the US is estimated to be around 20,000 patients per year.\n

Unverified Answer

What are common treatments for multiple myeloma?

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Multiple myeloma treatment is commonly used, either alone or as complement in other standard treatments. Monoclonal gammopathy of undetermined significance is commonly treated with alkylating agents. Patients with smoldering multiple myeloma are frequently treated with statins to reduce high lipid levels associated with this condition.

Unverified Answer

What are the common side effects of descartes 08?

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For those who wish to keep using medication, this information will help them know how they might be affected by the medications they have or have changed in recent years. If they have noticed side effects, they can take them directly to their physician and have them checked out. Some common, but mild, side effects of descartes 08 include: numbness, swelling, burning, and other types of pain. If they are taking drugs that have not been prescribed to them, their physician should also be notified. They should tell their physician all of their prescription drug usage and the amount and frequency of use.

Unverified Answer

What are the chances of developing multiple myeloma?

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The nromality of a group of people who were diagnosed with MM was about one third lower than that of the general population. To increase the detection rate of MM, screening programmes should start before the ndiscretionary age; the age range 45-64 years should be screened for MM. The ndiscretionary age of 65 years should receive screening for MM.

Unverified Answer

Does multiple myeloma run in families?

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Data from a recent study suggest that the occurrence of multiple myeloma is significantly increased in families when at least one member has one to two risk alleles. This finding underscores the importance of genetic counseling, particularly in families with multiple first-degree relatives affected early in life.

Unverified Answer

What is the primary cause of multiple myeloma?

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The risk of developing multiple myeloma increases as the number of risk factors increases. Multiple factors are associated with an increased risk of multiple myeloma, particularly cigarette smoking and viral infection but not sun exposure.

Unverified Answer

Have there been other clinical trials involving descartes 08?

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Findings from a recent study showed that, in vitro and in vivo studies have suggested that D8 could effectively inhibit multiple myeloma, although a larger number of patients are necessary to validate this hypothesis.

Unverified Answer

What is the latest research for multiple myeloma?

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A significant recent development involving the use of bortezomib in multiple myeloma has improved response rates. Further investigation into the use of bortezomib in multiple myeloma patients is warranted.

Unverified Answer
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