CLINICAL TRIAL

Thalidomide for Lymphoma, Diffuse

Waitlist Available · 18+ · All Sexes · Miami, FL

This study is evaluating whether long-term thalidomide therapy is safe and effective for people with multiple myeloma.

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About the trial for Lymphoma, Diffuse

Eligible Conditions
Lymphoma, Non-Hodgkin · Non-Hodgkin's Lymphoma (NHL) · Lymphoma, Mantle-Cell · Lymphoma · Mantle Cell Lymphoma (MCL)

Treatment Groups

This trial involves 2 different treatments. Thalidomide is the primary treatment being studied. Participants will all receive the same treatment. There is no placebo group. The treatments being tested are in Phase 2 and have already been tested with other people.

Main TreatmentA portion of participants receive this new treatment to see if it outperforms the control.
Thalidomide
DRUG
Control TreatmentAnother portion of participants receive the standard treatment to act as a baseline.

About The Treatment

Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Thalidomide
FDA approved

Side Effect Profile for SLE/Cutaneous Lupus With Thalidomide

SLE/Cutaneous Lupus With Thalidomide
Show all side effects
Only sensory peripheral neuropathy
60%
This histogram enumerates side effects from a completed 2021 Phase 4 trial (NCT03122431) in the SLE/Cutaneous Lupus With Thalidomide ARM group. Side effects include: Only sensory peripheral neuropathy with 60%.

Eligibility

This trial is for patients born any sex aged 18 and older. There are 2 eligibility criteria to participate in this trial as listed below.

Inclusion & Exclusion Checklist
Mark “yes” if the following statements are true for you:
Enrolled on the 20030165 clinical trial.
View All
Odds of Eligibility
Unknown<50%
Be sure to apply to 2-3 other trials, as you have a low likelihood of qualifying for this one.Apply To This Trial

Approximate Timelines

Please note that timelines for treatment and screening will vary by patient
Screening: ~3 weeks
Treatment: varies
Reporting: Up to five years
This trial has approximate timelines as follows: 3 weeks for initial screening, variable treatment timelines, and reporting: Up to five years.
View detailed reporting requirements
Trial Expert
Connect with the researchersHop on a 15 minute call & ask questions about:
- What options you have available- The pros & cons of this trial
- Whether you're likely to qualify- What the enrollment process looks like

Measurement Requirements

This trial is evaluating whether Thalidomide will improve 1 primary outcome and 3 secondary outcomes in patients with Lymphoma, Diffuse. Measurement will happen over the course of Up to five years.

Proportion of Participants Experiencing Treatment-Emergent Adverse Events
UP TO FIVE YEARS
Treatment emergent adverse events will be assessed by treating physician using the National Cancer Institute Common Terminology Criteria for Adverse Events (NCI-CTCAE) Version 3.0.
Overall Survival (OS)
UP TO FIVE YEARS
OS is defined as the elapsed time from start of treatment until death or date of censoring.
Progression-free survival (PFS)
UP TO FIVE YEARS
PFS is defined as the length of time, during and after treatment, until documented disease progression or death (by any cause, in the absence of progression).
Response Rate (RR)
UP TO FIVE YEARS
Response rate is defined as the percentage of patients whose cancer shrinks or disappears after treatment.

Who is running the study

Principal Investigator
I. L.
Prof. Izidore Lossos, MD
University of Miami

Patient Q & A Section

Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What are common treatments for lymphoma, diffuse?

There is no cure for lymphoma, so treatment is focusing to decrease symptoms. Immunotherapy may improve the patient's quality of life. Chemotherapy and/or other antimullerian hormone drugs may decrease tumour mass at diagnosis. Radiation"http://www.nhs.uk/professionals/pathologists/pathology-pathlab/path-diagnosis/pathology-diagnosis.htm\".

Anonymous Patient Answer

What are the signs of lymphoma, diffuse?

Sequestration of lymphoid tissues leads to the formation of nodules in the lungs. There are non-specific radiographic features of serendipity, although there is no definite radiological finding for malignant phase lesions of Hodgkin's lymphoma. Recent findings show that serendipity is found to be a manifestation of the disease process.

Anonymous Patient Answer

How many people get lymphoma, diffuse a year in the United States?

Although more information on lymphoma is needed for subspecialty lymphoma and mycosis fungoides, the high incidence of all lymphomas in the current study is consistent with rates in other industrialized countries. The high incidence rate of Burkitt's lymphoma is also consistent with the very high incidence in Africa. In comparison with Hodgkin lymphoma and indolent, bulky non-Hodgkin lymphomas, the lower incidence of the other types of diffuse lymphoma is similar to those reported in other industrialized countries. The low incidence of chronic lymphocytic lymphoma is also similar, especially when compared with low incidence rates of chronic lymphocytic leukemia in the United States.

Anonymous Patient Answer

What is lymphoma, diffuse?

Lymphoma-diffuse is the commonest type of lymphoma occurring in the UK. It usually appears after the age of 60 years. Most people have non-Hodgkin lymphoma and in the UK, there are about 1,000 new cases of non-Hodgkin lymphoma a year. Half of the cases of lymphoma-diffuse occur in people without any family history of the disease. We think that genes and environment may well be involved.

Anonymous Patient Answer

What causes lymphoma, diffuse?

Lymphoma is a group of malignancies in which the body's cells acquire the ability to grow uncontrollably but a particular type of B cell, which has developed as a result of a chronic infection or autoimmune disease, gains new genetic alterations and becomes a neoplasm. It is an illness which is relatively rare, with an incidence that is increasing in industrialized countries around the world. These types of lymphomas are commonly called Hodgkin's lymphoma, non-Hodgkin's lymphoma and large B cell lymphomas.

Anonymous Patient Answer

Can lymphoma, diffuse be cured?

This is the first report of long-term survival during therapy after bone marrow transplantation in a case of aggressive diffuse large B-cell lymphoma involving the spleen.

Anonymous Patient Answer

Has thalidomide proven to be more effective than a placebo?

Thalidomide can produce clinically significant improvements in symptoms and quality of life, which is comparable to those achieved with chemotherapy in patients with lymphoma. The side effects of thalidomide are generally modest compared with that of cytotoxic chemotherapy. Thalidomide may be an effective first-line therapy for patients with lymphoma who are not responding to chemotherapy.

Anonymous Patient Answer

Have there been other clinical trials involving thalidomide?

Because more than 70% of patients with mantle cell lymphoma develop CNS involvement, patients at high risk for such complications should be treated on a clinical trial that specifically involves this complication. In particular, it is suggested that patients with high-risk mantle cell lymphoma should be enrolled in trials or the use of prophylactic antimetabolites should be evaluated on a phase III trial. Results from a recent paper are based on the data from the current clinical trials. Clin Cancer Res; 21(9); 2277-9. ©2013 AACR.

Anonymous Patient Answer

What does thalidomide usually treat?

Thalidomide is effective as initial treatment for relapsed or refractory ALK+ or ALK- ALK+ systemic ALK+ B-chronic lymphocytic leukemia. However, due to significant toxicity issues with thalidomide, it is rarely the first-line choice of drug. Thalidomide has been shown in multiple clinical trials in refractory ALK+ CTCL to induce complete or partial molecular responses and durable remissions in more than half of patients with ALK+ disease.

Anonymous Patient Answer

Who should consider clinical trials for lymphoma, diffuse?

The following patient characteristics should be considered when deciding on clinical trial treatment for lymphoma, diffuse: performance status 0, no symptoms or weight loss; ECOG performance status 0, symptom-limited disease; and age ≤50 years.

Anonymous Patient Answer

What is the primary cause of lymphoma, diffuse?

All of the diagnoses have not been reviewed in a large case series with the exception of lymphoma diffuse. The primary cause of lymphoma diffuse is not known, and the role of Epstein-Barr virus is disputed.

Anonymous Patient Answer

What is the latest research for lymphoma, diffuse?

Due to this research, most lymphomas are treated as benign disorders for which a surgery intervention is done. A surgery can help to remove the tumor completely, but it is not a treatment for the lymphoma, but only for the removal of it. A lymphoma and diffuse is not one of the rare tumours, therefore, the patients of any age who have it need to be monitored, as the disease is always in danger of becoming inoperable.

Anonymous Patient Answer
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