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Glucagon-like peptide-1 receptor agonist

Semaglutide for Diabetic Kidney Disease (RAISE-KT Trial)

Phase 3
Waitlist Available
Led By Alex R Chang, MD, MS
Research Sponsored by Geisinger Clinic
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up baseline to 9 months
Awards & highlights

RAISE-KT Trial Summary

This trial looks at whether semaglutide, a diabetes medication, can help people with diabetes and kidney disease who are overweight or obese.

Eligible Conditions
  • Diabetic Kidney Disease
  • Obesity
  • Diabetes Mellitus
  • Chronic Kidney Disease

RAISE-KT Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~baseline to 9 months
This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline to 9 months for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Kidney Transplant Eligibility
Secondary outcome measures
Change in BMI
Change in Body Fat Percentage
Change in Hemoglobin A1c (HgbA1c)
+4 more
Other outcome measures
All-cause Hospitalizations
Cardiovascular Disease (CVD) Events
Change in Albuminuria Among Subset of Participants Without End-stage Kidney Disease
+15 more

RAISE-KT Trial Design

2Treatment groups
Active Control
Placebo Group
Group I: SemaglutideActive Control1 Intervention
This arm will receive semaglutide.
Group II: PlaceboPlacebo Group1 Intervention
This arm will receive placebo.

Find a Location

Who is running the clinical trial?

Geisinger ClinicLead Sponsor
148 Previous Clinical Trials
1,886,078 Total Patients Enrolled
Alex R Chang, MD, MSPrincipal InvestigatorGeisinger Clinic
1 Previous Clinical Trials
31 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Are there any Semaglutide-related fatalities on record?

"Semaglutide was given a score of 3 by our team at Power. This is due to this medication being in Phase 3 trials, which indicates that there is not just some evidence of efficacy, but multiple rounds of data supporting safety as well."

Answered by AI

What medical conditions respond well to Semaglutide?

"Semaglutide is frequently used to help patients manage their weight over the long term. Additionally, it can be employed as part of a treatment plan that includes a calorie-restricted diet, physical activity, and treating at least one other condition that is related to obesity."

Answered by AI

Are there any open slots for volunteers in this clinical trial?

"Correct, the information available on clinicaltrials.gov indicates that this study is actively looking for participants. The listing was created on 7/23/2021 and edited on 2/3/2022. They are hoping to recruit 150 patients from 2 locations."

Answered by AI

What other drugs has Semaglutide been tested against in a clinical setting?

"At the moment, 59 clinical trials concerning Semaglutide are active with 27 of them being Phase 3 research. Even though a few of the investigations for Semaglutide are happening near Loma Linda, 3899 other locations are conducting studies regarding Semaglutide."

Answered by AI

How many people are being included in this research project?

"Yes, as of February 3rd, 2022 this clinical trial is still seeking 150 participants from two different sites, as noted on clinicaltrials.gov"

Answered by AI

What are the unique aspects of this clinical trial?

"There are 59 ongoing clinical trials for Semaglutide in 766 cities and 55 nations. The first study was completed in 2018 by Novo Nordisk A/S. It reached Phase 4 approval after involving 1387 patients. In the two years since, 123 more trials have finished."

Answered by AI

Who else is applying?

What state do they live in?
Florida
Maryland
How old are they?
65+
What site did they apply to?
Geisinger Medical Center
What portion of applicants met pre-screening criteria?
Met criteria
Did not meet criteria
~4 spots leftby Apr 2025