Amlodipine for Conn Syndrome

Phase-Based Progress Estimates
Anand Vaidya, Boston, MAConn Syndrome+1 MoreAmlodipine - Drug
18 - 80
All Sexes
What conditions do you have?

Study Summary

This trial is testing whether a calcium channel blocker can help people with a certain type of hypertension caused by an excess of aldosterone.

Eligible Conditions
  • Conn Syndrome

Treatment Effectiveness

Effectiveness Progress

1 of 3

Study Objectives

2 Primary · 2 Secondary · Reporting Duration: 6 hours

2 weeks
Change in 24-hour Urinary Aldosterone Excretion Rate
Change in Plasma Aldosterone Concentration
6 hours
Acute change in Plasma Aldosterone Concentration
Acute change in Systolic Blood pressure

Trial Safety

Safety Progress

2 of 3
This is further along than 68% of similar trials

Side Effects for

Aim 1- Low Sodium
4%Low glucose
4%viral illness
This histogram enumerates side effects from a completed 2019 Phase 4 trial (NCT02034435) in the Aim 1- Low Sodium ARM group. Side effects include: Headache with 7%, numbness with 4%, Low glucose with 4%, viral illness with 4%, Dizziness/Lightheadedness with 4%.

Trial Design

1 Treatment Group

1 of 1

Experimental Treatment

15 Total Participants · 1 Treatment Group

Primary Treatment: Amlodipine · No Placebo Group · Phase 2

Experimental Group · 1 Intervention: Amlodipine · Intervention Types: Drug
First Studied
Drug Approval Stage
How many patients have taken this drug
FDA approved

Trial Logistics

Trial Timeline

Screening: ~3 weeks
Treatment: Varies
Reporting: 6 hours

Who is running the clinical trial?

Brigham and Women's HospitalLead Sponsor
1,497 Previous Clinical Trials
10,479,555 Total Patients Enrolled
University of MichiganOTHER
1,645 Previous Clinical Trials
6,417,808 Total Patients Enrolled
Anand Vaidya, MDPrincipal Investigator - Brigham and Women's Hospital
Boston Children's Hospital, Dana-Farber Cancer Institute
Harvard Medical Sch (Medical School)
Brigham & Women'S Hospital (Residency)
2 Previous Clinical Trials
106 Total Patients Enrolled

Eligibility Criteria

Age 18 - 80 · All Participants · 4 Total Inclusion Criteria

Mark “Yes” if the following statements are true for you:
You are currently taking medication to treat primary aldosteronism but have not had surgery.

Frequently Asked Questions

How many individuals have been recruited for this research initiative?

"Affirmative. According to, this research is currently sourcing participants since its first posting on September 1st 2020 and last update November 26th 2021. The study requires 15 patients from a single medical centre for enrollment." - Anonymous Online Contributor

Unverified Answer

Are there any specific criteria for enrolling in this research project?

"Candidates wishing to take part in the trial must suffer from adrenogenital syndrome and be between 18 and 80 years of age. In total, this medical study is enrolling 15 individuals." - Anonymous Online Contributor

Unverified Answer

Are individuals younger than sixty years of age being considered for participation in this clinical study?

"This clinical trial is open to participants aged 18 and over, up to a maximum of 80 years old." - Anonymous Online Contributor

Unverified Answer

In which medical conditions is Amlodipine commonly prescribed?

"Amlodipine is typically prescribed to manage cardiovascular issues, such as dyslipidemias, coronary artery disease (CAD), and high risk cardiopathy." - Anonymous Online Contributor

Unverified Answer

What adverse effects might be incurred by using Amlodipine?

"Amlodipine's safety was rated a 2 out of 3, as this is still an early phase trial and there has been no conclusive data yet surrounding its efficacy." - Anonymous Online Contributor

Unverified Answer

Are there currently any openings to take part in this clinical experiment?

" states that this trial is still admiting participants, having been initially posted on September 1st 2020 and recently updated on November 26th 2021." - Anonymous Online Contributor

Unverified Answer

Can you provide information on any past experiments that have included Amlodipine?

"Presently, 29 trials related to Amlodipine are taking place. 6 of those clinical studies have reached Phase 3 status and span across 318 medical centres with the majority being located in Boston, MA." - Anonymous Online Contributor

Unverified Answer
Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.