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ACE Inhibitors and Diuretics for Pre-eclampsia (ACE Trial)
ACE Trial Summary
This trial will compare two types of blood pressure medication to see which is more effective.
- Postpartum preeclampsia
- Hypertension
ACE Trial Timeline
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.ACE Trial Design
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Who is running the clinical trial?
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- You have a condition called angioedema that may be inherited or has an unknown cause.You are allergic to ACE inhibitors or sulfa drugs.You have very advanced kidney disease.
- Group 1: Hctz/Lisinopril
- Group 2: Extended release nifedipine
- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
- Pivotal Trial - The final step before approval, pivotal trials feature drugs that have already shown basic safety & efficacy.
- Drug Has Already Been Approved - The FDA has already approved this drug, and is just seeking more data.
- Approved for 5 Other Conditions - This treatment demonstrated efficacy for 5 other conditions.
- All Individual Drugs Already Approved - Therapies where all constituent drugs have already been approved are likely to have better-understood side effect profiles.
- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
What is the upper limit of individuals who are taking part in this experiment?
"Affirmative. Records hosted on clinicaltrials.gov verify that this medical trial, published online on the 18th of October 2021, is still ongoing and recruiting participants from one centre - with an intended enrollment of 60 patients in total."
Are ACE Inhibitors and Diuretics a safe option for individuals?
"Our team at Power have assigned a score of 3 to ACE Inhibitors and Diuretics due to the extensive clinical data that supports its safety. This treatment is already approved in Phase 4 trials."
In what scenarios are ACE Inhibitors and Diuretics frequently administered?
"Vasospastic angina is typically managed using ACE Inhibitors and Diuretics. These medications may also be able to aid in the treatment of varied conditions like other and unspecified effects of high altitude, premature labour, as well as achalasia."
Are there any precedents for combining ACE Inhibitors and Diuretics in clinical trials?
"Presently, 11 clinical trials are being run with ACE Inhibitors and Diuretics as the primary intervention. Of those 11 operations, 3 have reached Phase 3. Despite 85 different research sites in Breckenridge Colorado conducting experiments concerning this treatment, only one is currently active."
Does this trial mark a pioneering step in medical research?
"ACE Inhibitors and Diuretics were first studied in 2007 when a trial sponsored by Encysive Pharmaceuticals was conducted with 27 participants. Subsequently, ACE Inhibitors and Diuretics received Phase 2 drug approval before 11 separate trials began across 62 cities worldwide within 5 different countries."
Are new participants still being accepted for this research endeavor?
"Affirmative. Clinicaltrials.gov demonstrates that this clinical trial, published on October 18th 2021 and updated lastly on the 22nd of same month, is currently in need of 60 individuals to fill 1 medical centre's quota."
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