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Cancer Vaccine

Sulforaphane tablets for Alcoholism

N/A

Recruiting

Led By Aline Zaparte, PhD

Research Sponsored by Louisiana State University Health Sciences Center in New Orleans

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up change in serum interleukin-6 levels after 28 days of intervention.

Awards & highlights

Study Summary

This trial will test if a compound found in broccoli sprouts extract can help improve gut health in individuals with poor nutrition and alcohol use. Chronic alcohol consumption can disrupt the balance of bacteria in the gut,

Who is the study for?

This trial is for adults over 50 who have a poor diet (HEI score below 51) and consume at least 8 alcoholic drinks per week, with an AUDIT-C score greater than 8. It's not suitable for those who don't meet these specific alcohol and dietary criteria.Check my eligibility

What is being tested?

The study is testing the effects of broccoli sprout extract, which contains sulforaphane, against a placebo to see if it can improve gut health by reducing inflammation and oxidative stress in older adults with poor nutrition and regular alcohol use.See study design

What are the potential side effects?

Broccoli sprout extract is considered safe but may cause gas or bloating. Since it's being tested as a supplement, other side effects are not well-known but could include allergic reactions or interactions with medications.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ change in serum levels of intestine acid biding proteins after 28 days of intervention.

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~change in serum levels of intestine acid biding proteins after 28 days of intervention.

This trial's timeline: 3 weeks for screening, Varies for treatment, and change in serum levels of intestine acid biding proteins after 28 days of intervention. for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Change of Inflammation biomarkers

Change on the Leaky gut biomarker

Side effects data

From 2013 Phase 2 trial • 44 Patients • NCT01474993

19%

Vomiting

15%

Abdominal pain

15%

Increased Flatulence

15%

SGPT outside of reference range

15%

Increased aggressions

12%

Increased irritability

12%

Constipation

12%

Diarrhea

12%

Seasonal allergy exacerbation

12%

Fever

12%

Headache

Insomnia

Increased stubbornness

Abnormal WBC count

Seizures

Cough

Hyperactivity

Increased appetite

Abnormal platelet count

TSH outside of reference range

Increased agitation

Crying spells

100%

80%

60%

40%

20%

Study treatment Arm

Placebo

Sulforaphane-rich Broccoli Sprout Extract

Trial Design

2Treatment groups

Experimental Treatment

Placebo Group

Group I: Sulforaphane tabletsExperimental Treatment1 Intervention

People in the experimental group will be advised to take 2 tablets a day with a meal for 28 days.

Group II: Placebo tabletsPlacebo Group1 Intervention

People in the placebo group will be advised to take 2 tablets a day with a meal for 28 days.

Do I qualify?Apply below to find out

Find a Location

Who is running the clinical trial?

Louisiana State University Health Sciences Center in New OrleansLead Sponsor

114 Previous Clinical Trials

44,161 Total Patients Enrolled

1 Trials studying Alcoholism

68 Patients Enrolled for Alcoholism

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)NIH

2,359 Previous Clinical Trials

4,314,552 Total Patients Enrolled

1 Trials studying Alcoholism

70 Patients Enrolled for Alcoholism

Aline Zaparte, PhDPrincipal InvestigatorPostdoctoral Fellow

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Are individuals who are older than 65 eligible to participate in this research study?

"To meet the entry requirements for this research study, participants must be at least 50 years old but no older than 80."

Answered by AI

Is the enrollment phase for this investigation currently ongoing?

"As per clinicaltrials.gov, this study is actively seeking volunteers. The initial posting of the trial occurred on January 23rd, 2024, with the most recent update made on March 11th, 2024."

Answered by AI

Which individuals meet the eligibility criteria to participate in this scientific experiment?

"Candidates must be diagnosed with alcohol use disorder and fall between the ages of 50 to 80 to meet the criteria for this research study. A total of 40 subjects are sought for participation in this trial."

Answered by AI

How many individuals in total are involved as participants in this research investigation?

"Indeed, information available on clinicaltrials.gov indicates that this study is actively seeking participants. The trial was initially uploaded on January 23rd, 2024 and last modified on March 11th, 2024. It aims to recruit a total of 40 patients from one specified site."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

Broccoli Extract Supplementation in Older Adults With Alcohol Use Disorder

Aline Zaparte 2024. "Broccoli Extract Supplementation in Older Adults With Alcohol Use Disorder". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT05902754.