Stereotactic Body Radiation Therapy for Prostate Cancer

Phase-Based Progress Estimates
1
Effectiveness
2
Safety
UCLA / Jonsson Comprehensive Cancer Center, Los Angeles, CAProstate Cancer+5 MoreStereotactic Body Radiation Therapy - Radiation
Eligibility
18+
Male
What conditions do you have?
Select

Study Summary

This trial is testing a new, more precise way of doing radiation therapy that may be more effective and have fewer side effects than the current standard.

Eligible Conditions
  • Stage IVB Prostate Cancer
  • Prostate Adenocarcinoma
  • Stage IIIB Prostate Cancer
  • Stage III Prostate Cancer
  • Stage IV Prostate Cancer
  • Stage IVA Prostate Cancer

Treatment Effectiveness

Effectiveness Progress

1 of 3

Similar Trials

1
Stereotactic Body Radiation Therapy
1
Stereotactic Body Radiation Therapy
1
Stereotactic Body Radiation Therapy

Study Objectives

2 Primary · 7 Secondary · Reporting Duration: Up to 5 years

Year 5
Patient-reported gastrointestinal (GI) symptoms
Patient-reported genitourinary (GU) symptoms
Year 2
Change of Expanded Prostate Cancer Index (EPIC) score for the gastrointestinal domain
Change of Expanded Prostate Cancer Index (EPIC) score for the genitourinary domain
Up to 5 years
Cumulative incidence of biochemical recurrence
Cumulative incidence of physician scored adverse events
Distant metastasis-free survival
Incidence of acute physician scored adverse events
Progression-free survival

Trial Safety

Safety Progress

2 of 3
This is further along than 68% of similar trials

Similar Trials

2
Stereotactic Body Radiation Therapy
2
Stereotactic Body Radiation Therapy
2
Stereotactic Body Radiation Therapy

Side Effects for

Treatment (Chemotherapy, Oregovomab, SBRT, Surgery)
55%Leukopenia
36%Thrombocytopenia
36%Lymphopenia
18%AST elevation
18%ALT elevation
18%Anemia
18%Reduced ANC
9%Urinary tract infection
9%Sinusitis
9%Pneumonia
9%Sepsis
9%Pleural effusion
9%Pancreatitis
9%Hyperkalemia
9%Acidosis
9%Cardiac disorders
9%Orthostasis
9%Rash
9%Nausea
9%Vomiting
9%Dehydration
9%Depression
9%Somnolence
9%Hypokalemia
This histogram enumerates side effects from a completed 2018 Phase 2 trial (NCT01959672) in the Treatment (Chemotherapy, Oregovomab, SBRT, Surgery) ARM group. Side effects include: Leukopenia with 55%, Thrombocytopenia with 36%, Lymphopenia with 36%, AST elevation with 18%, ALT elevation with 18%.

Trial Design

1 Treatment Group

Treatment (SBRT, hormone therapy)
1 of 1

Experimental Treatment

102 Total Participants · 1 Treatment Group

Primary Treatment: Stereotactic Body Radiation Therapy · No Placebo Group · Phase 2

Treatment (SBRT, hormone therapy)Experimental Group · 2 Interventions: Hormone Therapy, Stereotactic Body Radiation Therapy · Intervention Types: Drug, Radiation
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Hormone Therapy
2015
Completed Phase 2
~50
Stereotactic Body Radiation Therapy
2019
Completed Phase 2
~650

Trial Logistics

Trial Timeline

Screening: ~3 weeks
Treatment: Varies
Reporting: up to 5 years

Who is running the clinical trial?

Jonsson Comprehensive Cancer CenterLead Sponsor
340 Previous Clinical Trials
21,642 Total Patients Enrolled
37 Trials studying Prostate Cancer
3,890 Patients Enrolled for Prostate Cancer
Amar KishanPrincipal InvestigatorUCLA / Jonsson Comprehensive Cancer Center
4 Previous Clinical Trials
625 Total Patients Enrolled

Eligibility Criteria

Age 18+ · Male Participants · 10 Total Inclusion Criteria

Mark “Yes” if the following statements are true for you:
References

Frequently Asked Questions

Are there any current vacancies for this research project?

"The study, which you can find more information about on clinicaltrials.gov, is still looking for participants. The post date was June 23rd 2021 and the most recent edit was on July 1st of this year." - Anonymous Online Contributor

Unverified Answer

Are there any harmful after-effects of Stereotactic Body Radiation Therapy?

"Although Phase 2 trials offer preliminary evidence of a treatment's safety, there is no data supporting its efficacy. For this reason, our team has given Stereotactic Body Radiation Therapy a score of 2." - Anonymous Online Contributor

Unverified Answer

To date, how many individuals have taken part in this research?

"The listing on clinicaltrials.gov verifies that the research team is still looking for test subjects. The study was put up on 23 June 2021 and edited most recently on 1 July 2022; they are seeking 102 individuals total at a single site." - Anonymous Online Contributor

Unverified Answer
Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Unbiased ResultsWe believe in providing patients with all the options.
Your Data Stays Your DataWe only share your information with the clinical trials you're trying to access.
Verified Trials OnlyAll of our trials are run by licensed doctors, researchers, and healthcare companies.
Back to top