Fisetin for Femoroacetabular Impingement

Recruiting in Palo Alto (17 mi)

Overseen byJohnny L Huard, PhD

Age: 18+

Sex: Any

Travel: May Be Covered

Time Reimbursement: Varies

Trial Phase: Phase 1 & 2

Waitlist Available

Sponsor: Steadman Philippon Research Institute

Trial Summary

What is the purpose of this trial?This trial is testing if Fisetin, which removes old, damaged cells, can help patients with hip issues heal better after surgery by reducing inflammation.

Eligibility Criteria

Adults aged 18-80 with femoroacetabular impingement (FAI) or a hip labral tear, who can consent and follow study procedures. They must be scheduled for hip arthroscopy but cannot have had previous significant hip surgeries, systemic autoimmune diseases, uncontrolled diabetes, recent use of certain drugs like warfarin or senolytic agents, or conditions that could interfere with the trial.

Inclusion Criteria

I am scheduled for hip surgery to address FAI or a hip labral tear.

I am between 18 and 80 years old.

I have been diagnosed with FAI or a hip labral tear.

+1 more

Exclusion Criteria

Joint space less than or equal to 2mm

I have been diagnosed with fibromyalgia.

History of drug and/or alcohol abuse

+20 more

Participant Groups

The trial is testing whether Fisetin (a drug thought to remove aging cells) can enhance the effects of Platelet-Rich Plasma and losartan in treating FAI and labral tears when used before and after surgery. A placebo group will serve as a comparison to measure Fisetin's effectiveness.

2Treatment groups

Experimental Treatment

Placebo Group

Group I: Fisetin group (investigational group)Experimental Treatment1 Intervention

20mg/kg of Fisetin per day for days 1 and 2 prior to surgery and days 33, 34, 63, 64, 93, and 94 post surgery. (The pills are 100mg each. For example, if a participant weighs 160 pounds (about 73 kg), the participant will need to take 15 pills per day)

Group II: Placebo group (control group)Placebo Group1 Intervention

20mg/kg of Placebo per day for days 1 and 2 prior to surgery and days 33, 34, 63, 64, 93, and 94 post surgery. (The pills are 100mg each. For example, if a participant weighs 160 pounds (about 73 kg), the participant will need to take 15 pills per day)