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GLP-1 Receptor Agonist and SGLT2 Inhibitor Combination

Empagliflozin 25 MG + Liraglutide 1.8 MG for Type 2 Diabetes (NATRIURETIC Trial)

Phase 2
Recruiting
Led By David ZI Cherney, MD PhD FRCPC
Research Sponsored by University Health Network, Toronto
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up outcome will be measured at 2 time points: monotherapy (6 weeks) and combination therapy (12 weeks)
Awards & highlights

NATRIURETIC Trial Summary

This trial studies how two diabetes treatments affect heart health in people with type 2 diabetes without heart failure.

Eligible Conditions
  • Type 2 Diabetes

NATRIURETIC Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~glomerular filtration rate (gfr, based on plasma iohexol clearance) will be measured at 2 time points: monotherapy (6 weeks) and combination therapy (12 weeks)
This trial's timeline: 3 weeks for screening, Varies for treatment, and glomerular filtration rate (gfr, based on plasma iohexol clearance) will be measured at 2 time points: monotherapy (6 weeks) and combination therapy (12 weeks) for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Proximal tubular natriuresis
Secondary outcome measures
Arterial stiffness
Body weight
Glomerular Filtration Rate
+4 more

NATRIURETIC Trial Design

2Treatment groups
Experimental Treatment
Group I: LiraglutideExperimental Treatment2 Interventions
Liraglutide Subcutaneous Total Dose 1.8mg daily for 6 weeks
Group II: EmpagliflozinExperimental Treatment2 Interventions
Empagliflozin Tablets Total Dose 25mg daily for 6 weeks

Find a Location

Who is running the clinical trial?

University Health Network, TorontoLead Sponsor
1,468 Previous Clinical Trials
484,483 Total Patients Enrolled
David ZI Cherney, MD PhD FRCPCPrincipal InvestigatorUniversity Health Network, Toronto General Hospital
1 Previous Clinical Trials
50 Total Patients Enrolled

Media Library

Empagliflozin 25 MG + Liraglutide 1.8 MG (GLP-1 Receptor Agonist and SGLT2 Inhibitor Combination) Clinical Trial Eligibility Overview. Trial Name: NCT04535960 — Phase 2
Type 2 Diabetes Research Study Groups: Liraglutide, Empagliflozin
Type 2 Diabetes Clinical Trial 2023: Empagliflozin 25 MG + Liraglutide 1.8 MG Highlights & Side Effects. Trial Name: NCT04535960 — Phase 2
Empagliflozin 25 MG + Liraglutide 1.8 MG (GLP-1 Receptor Agonist and SGLT2 Inhibitor Combination) 2023 Treatment Timeline for Medical Study. Trial Name: NCT04535960 — Phase 2

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is this experiment currently admitting participants?

"The information on clinicaltrials.gov confirms that this medical trial is not currently enrolling patients. Initially posted on January 24th 2019, it was last updated September 1st 2020 and no longer seeks participants; however, 2261 other studies are still actively recruiting at the moment."

Answered by AI

To what medical conditions is Empagliflozin 25 MG + Liraglutide 1.8 MG prescribed?

"Empagliflozin 25 MG + Liraglutide 1.8MG is frequently utilized for hospitalizations, but can also be used therapeutically to combat diet-related issues, inadequate control when relying upon a single medication treatment plan, and cardiovascular diseases."

Answered by AI

To what extent does the combination of Empagliflozin 25 MG + Liraglutide 1.8 MG pose a risk to patients?

"Due to the lack of clinical data that has been gathered on efficacy, Empagliflozin 25 MG + Liraglutide 1.8 MG was given a rating of 2 for safety based on our team's assessment at Power."

Answered by AI

To what capacity is this investigation accommodating participants?

"At this time, recruitment for the trial is closed. The initial posting was on January 24th 2019 and the most recent update occurred in September 2020. If searching for other studies with a similar diagnosis, 2187 trials are currently recruiting patients diagnosed with type 2 diabetes, while 74 clinical trials are seeking participants to test Empagliflozin 25 MG + Liraglutide 1.8 MG as an intervention."

Answered by AI
~6 spots leftby Apr 2025