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VLX-1005 for Heparin Induced Thrombocytopenia

Phase 1
Waitlist Available
Led By Allen Hunt, MBA
Research Sponsored by Veralox Therapeutics
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be between 18 and 65 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 0 - 30 days
Awards & highlights

Study Summary

This trial will study the effects of two drugs, VLX-1005 and argatroban, on healthy subjects. Researchers will assess safety, tolerability, and how the drugs interact with each other.

Eligible Conditions
  • Heparin Induced Thrombocytopenia

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~0 - 30 days
This trial's timeline: 3 weeks for screening, Varies for treatment, and 0 - 30 days for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Effects of VLX-1005 on AUC(inf) of argatroban
Effects of VLX-1005 on Cmax of argatroban
Effects of VLX-1005 on PFA-100
+7 more
Secondary outcome measures
Effects of VLX-1005 on 12-HETE
Effects of argatroban on 12-HETE
Safety as measured by incidence of Treatment Emergent Adverse Events

Trial Design

3Treatment groups
Experimental Treatment
Active Control
Group I: VLX-1005 and ArgatrobanExperimental Treatment2 Interventions
Intravenous co-administration of VLX-1005 and argatroban with measurements of PK and PD
Group II: VLX-1005Experimental Treatment1 Intervention
Intravenous administration of VLX-1005 with measurements of PK and PD
Group III: ArgatrobanActive Control1 Intervention
Intravenous administration of argatroban with measurements of PK and PD
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
VLX-1005
2022
Completed Phase 1
~110
Argatroban
FDA approved

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Logistics

Participation is compensated

You will be compensated for participating in this trial.

Who is running the clinical trial?

Veralox TherapeuticsLead Sponsor
2 Previous Clinical Trials
156 Total Patients Enrolled
CelerionIndustry Sponsor
81 Previous Clinical Trials
7,802 Total Patients Enrolled
Allen Hunt, MBAPrincipal InvestigatorCelerion

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
clinicaltrials.govStudy
A Phase I Study of the Co-administration of VLX-1005 and Argatroban in Healthy Human Subjects
2022. "A Phase I Study of the Co-administration of VLX-1005 and Argatroban in Healthy Human Subjects". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT05325346.
~4 spots leftby Apr 2025
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