Oral Nicotine Pouches vs Electronic Cigarettes for Smoking
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial aims to understand how different tobacco users experience oral nicotine products compared to electronic cigarettes. Researchers seek to determine which of these products might be more appealing or satisfying for individuals who smoke cigarettes or use other forms of smokeless tobacco. Participants will try both an oral nicotine pouch and an electronic cigarette to compare their experiences. This trial suits daily smokers or smokeless tobacco users who can refrain from using their regular products for 8-10 hours before study visits. As an unphased trial, it offers participants the opportunity to contribute to important research that could shape future tobacco harm reduction strategies.
Will I have to stop taking my current medications?
The trial information does not specify if you need to stop taking your current medications. However, you must abstain from using cigarettes or smokeless tobacco for 8-10 hours before study visits.
Is there any evidence suggesting that this trial's treatments are likely to be safe?
Research shows that both electronic cigarettes and oral nicotine pouches present safety concerns. Studies have found that electronic cigarettes produce harmful chemicals like formaldehyde, which can damage the lungs. Users might also experience coughing, shortness of breath, and headaches.
Although less information is available for oral nicotine pouches, they also pose risks. Nicotine is highly addictive and can harm unborn babies. Using these pouches might increase heart rate and blood pressure, potentially leading to heart problems.
Neither product is risk-free, and both can negatively affect health. Considering these risks is important when deciding to join a trial involving these products.12345Why are researchers excited about this trial?
Researchers are excited about these treatments because they offer new ways to deliver nicotine compared to traditional smoking cessation aids like nicotine patches, gums, or lozenges. Electronic cigarettes and oral nicotine pouches like ZYN provide a unique sensory experience and deliver nicotine differently by mimicking the act of smoking or providing a discreet, smokeless option. This could be appealing to those who miss the ritual of smoking or prefer a less conspicuous way to manage nicotine cravings. These alternatives might help more people transition away from combustible tobacco products by offering customizable and potentially less harmful options.
What evidence suggests that this trial's treatments could be effective for nicotine users?
Research has shown that electronic cigarettes can help people quit smoking more effectively than counseling alone. For example, one study found that individuals using e-cigarettes to quit had higher success rates, with some reporting a 70% success rate when used regularly. In this trial, participants will use electronic cigarettes as one of the treatment options.
Conversely, oral nicotine pouches, also studied in this trial, have been found to help reduce smoking, particularly for those willing to try them. However, some evidence suggests they might not be as effective as e-cigarettes for complete smoking cessation. Despite this, oral nicotine pouches can still help people smoke fewer cigarettes. Overall, both options in this trial have shown promise in helping people cut down or quit smoking.678910Who Is on the Research Team?
Maciej Goniewicz, PhD
Principal Investigator
Roswell Park Comprehensive Cancer Center
Are You a Good Fit for This Trial?
Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants use oral nicotine products and electronic cigarettes for up to 30 minutes per session
Follow-up
Participants are monitored for safety and effectiveness after treatment
Long-term follow-up
Participants' sensory responses are monitored over an extended period
What Are the Treatments Tested in This Trial?
Interventions
- Electronic Cigarette
- Oral Nicotine Pouch
Find a Clinic Near You
Who Is Running the Clinical Trial?
Roswell Park Cancer Institute
Lead Sponsor