15 Participants Needed

Comparing Nicotine Delivery, Subjective Effects, and Sensory Experiences of Tobacco Users Using Oral Nicotine Products and Electronic Cigarettes [ZYN Study]

NF
MG
Overseen ByMaciej Goniewicz, PhD
Age: 18 - 65
Sex: Any
Trial Phase: Academic
Sponsor: Roswell Park Cancer Institute
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial tests how appealing ZYN, a nicotine pouch, is to people who use cigarettes, smokeless tobacco, and other nicotine products. ZYN offers a tobacco-free way to consume nicotine and delivers it quickly without significant adverse effects.

Who Is on the Research Team?

MG

Maciej Goniewicz, PhD

Principal Investigator

Roswell Park Comprehensive Cancer Center

Are You a Good Fit for This Trial?

Inclusion Criteria

You smoke more than 5 cigarettes per day for at least 1 year.
Self-report fair or better physical health.
Willingness to abstain from using cigarettes/ST (smokeless tobacco) for 8-10 hours (overnight abstinence) prior to study visits (verified by exhaled-air carbon monoxide < 10ppm).
See 7 more

Exclusion Criteria

You have experienced severe side effects from nicotine or any nicotine replacement products in the past.
Any condition which in the Investigator's opinion deems the participant an unsuitable candidate to receive study drug.
Nursing female participants.
See 6 more

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Treatment

Participants use oral nicotine products and electronic cigarettes for up to 30 minutes per session

4 weeks
Multiple sessions (in-person)

Follow-up

Participants are monitored for safety and effectiveness after treatment

4 weeks

Long-term follow-up

Participants' sensory responses are monitored over an extended period

1 year

What Are the Treatments Tested in This Trial?

Interventions

  • Electronic Cigarette
  • Oral Nicotine Pouch
How Is the Trial Designed?
2Treatment groups
Experimental Treatment
Group I: Order 2 - Electronic Cigarettes and Oral Nicotine productExperimental Treatment2 Interventions
Group II: Order 1 - Oral Nicotine product - ZYN and Electronic CigarettesExperimental Treatment2 Interventions

Find a Clinic Near You

Who Is Running the Clinical Trial?

Roswell Park Cancer Institute

Lead Sponsor

Trials
427
Recruited
40,500+
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