Electronic Cigarette for Smoking, Cigarette

Phase-Based Progress Estimates
1
Effectiveness
1
Safety
Roswell Park Comprehensive Cancer Center, Buffalo, NY
Smoking, Cigarette+3 More
Electronic Cigarette - Other
Eligibility
18 - 65
All Sexes
Eligible conditions
Select

Study Summary

This study is evaluating whether non-tobacco oral nicotine products are appealing to cigarette smokers.

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Eligible Conditions

  • Smoking, Cigarette
  • Tobacco Use
  • Tobacco Smoking Behavior
  • Smokeless Tobacco Cessation

Treatment Effectiveness

Effectiveness Estimate

1 of 3

Study Objectives

This trial is evaluating whether Electronic Cigarette will improve 2 primary outcomes and 1 secondary outcome in patients with Smoking, Cigarette. Measurement will happen over the course of Up to 4 weeks.

Up to 4 weeks
Change is stress markers
up to 1 year
Change in sensory response
up to week 4
Change in nicotine boost

Trial Safety

Safety Estimate

1 of 3

Trial Design

2 Treatment Groups

Order 1 - Oral Nicotine product - ZYN and Electronic Cigarettes
1 of 2
Order 2 - Electronic Cigarettes and Oral Nicotine product
1 of 2
Experimental Treatment

This trial requires 20 total participants across 2 different treatment groups

This trial involves 2 different treatments. Electronic Cigarette is the primary treatment being studied. Participants will be divided into 2 treatment groups. There is no placebo group. The treatments being tested are not being studied for commercial purposes.

Order 1 - Oral Nicotine product - ZYN and Electronic CigarettesParticipants will use each product for up to a 30 minute interval But will also be permitted to stop use before the end of the 30-minute ad lib use period
Order 2 - Electronic Cigarettes and Oral Nicotine productParticipants will use each prodcut for up to 30 minutes but will also be permitted to stop use before the end of the 30-minute ad lib use period

Trial Logistics

Trial Timeline

Approximate Timeline
Screening: ~3 weeks
Treatment: Varies
Reporting: up to 1 year
This trial has the following approximate timeline: 3 weeks for initial screening, variable treatment timelines, and roughly up to 1 year for reporting.

Closest Location

Roswell Park Comprehensive Cancer Center - Buffalo, NY

Eligibility Criteria

This trial is for patients born any sex between 18 and 65 years old. There are 6 eligibility criteria to participate in this trial as listed below.

Mark “yes” if the following statements are true for you:
Smokes >5 cigarettes/day for >1 year OR a. Uses >=5 units/day for >=1 year
You use portions of moist snuff, loose moist snuff or nicotine patches. show original
Willingness to abstain from using cigarettes/ST (smokeless tobacco) for 8-10 hours (overnight abstinence) prior to study visits (verified by exhaled-air carbon monoxide < 10ppm).
You have a self-report of fair or better physical health. show original
Self-report fair or better mental health. show original
You must understand the investigational nature of this study and sign an Independent Ethics Committee/Institutional Review Board approved written informed consent form prior to receiving any study related products. show original

Patient Q&A Section

What causes smoking, cigarette?

"Over 75% of the population has been exposed to smoking via passive means. Smokers are generally concerned about the health risks of smoking, but as a result of their own negative views, are reluctant to acknowledge the risks and are not supported by their friends. A more negative media portrayal of smoking may be the real culprit." - Anonymous Online Contributor

Unverified Answer

How many people get smoking, cigarette a year in the United States?

"Cigarette smoking has become so embedded in our culture that some people may smoke a cigarette and never breathe a breath again. Cigarette smoking, as an important lifestyle determinant of chronic diseases, needs to be targeted in preventive screening and cessation strategies to further reduce smoking prevalence." - Anonymous Online Contributor

Unverified Answer

Can smoking, cigarette be cured?

"Tobacco (smoking, cannabis) does NOT cure disease (rheumatoid arthritis, multiple sclerosis, asthma, cancer). Treating chronic disease (smoking) with smoking, smoking, cannabis alone or in combination is not a cure for disease. Rather, smoking should be reduced or discontinued." - Anonymous Online Contributor

Unverified Answer

What are the signs of smoking, cigarette?

"The signs and symptoms of smoking are primarily due to tobacco, which in turn is caused by the smoke of cigarettes. They include coughing and shortness of breath, as well as nausea, a fast heart rate, headaches and weight gain. Other signs and symptoms of smoking include weight loss, skin changes, mouth or throat irritation, a dulled reflex to light touch, and decreased endurance when exercising. Smoking may result in [bladder cancer](https://www.withpower.com/clinical-trials/bladder-cancer), COPD, cancer deaths and other problems.\n" - Anonymous Online Contributor

Unverified Answer

What are common treatments for smoking, cigarette?

"Most smokers are trying to quit or have stopped. Common treatment options include counseling, nicotine replacement therapy, and smoking cessation interventions. Behavioral interventions tend to be more effective than medications. Smoking cessation interventions should be tailored to the strengths and weaknesses of each individual patient and should focus on the psychological and social barriers that are important for quitting and staying smoke-free." - Anonymous Online Contributor

Unverified Answer

What is smoking, cigarette?

"Approximately 90 million Americans smoke cigarettes in a given year, and over half of that number are smokers who want to lessen their cigarette smoking. The US Preventive Services Task force's (USPSTF) 2009 report, in its guidelines for assessing the effectiveness of interventions and its guidelines on tobacco prevention, stated that evidence is sufficient to advise the clinician that smoking cessation interventions (such as nicotine replacement therapy) are probably effective with respect to reducing total cessation effort. The USPSTF also stated, however, that, because there were few good control trials, more than 10% of smokers achieved complete cessation, and little is known about whether those who cease are still at risk for subsequent smoking." - Anonymous Online Contributor

Unverified Answer

Have there been any new discoveries for treating smoking, cigarette?

"In 2010-2013, there was a significant increase in the number of publications that reported the results of new trials with some type of pharmaceutical drug or treatment for smoking, with a significant increase in comparison with the previous 5 years. Most studies reported results of high-quality randomized trials. In general, the results were consistent with what had been reported in previous studies." - Anonymous Online Contributor

Unverified Answer

What are the latest developments in electronic cigarette for therapeutic use?

"All of the manufacturers of e-cigarettes that participated in the project report a growing use of e-cigarettes among their customers. Almost half of the respondents think that the potential risks must be considered against the health benefits of the treatment. In addition, e-cigarettes should be considered for use in smokers who prefer to quit (as opposed to smokers who have tried to quit but are not successful). There is great variability between e-cigarette companies in what terms such as "e-liquid", "liquid e-cigarette" or "e-cigarette" are preferred." - Anonymous Online Contributor

Unverified Answer

What are the common side effects of electronic cigarette?

"In a recent study, findings provide evidence that most e-cigarette users cite common side effects, and it is likely that the prevalence of these side effects is influenced by product design. These side effects may affect long-term health risks associated with regular e-cigarette use and should be considered when assessing the safety of e-cigarettes in research and clinical care." - Anonymous Online Contributor

Unverified Answer

How serious can smoking, cigarette be?

"Smoked, cigarette is likely to cause many illnesses, both immediate and long-term. Most smokers begin to smoke before age 18. More than half smoked their first cigarette(s) between the ages of 17 and 20. Smoking in early adolescence increases the chances of being a heavy smoker in later life." - Anonymous Online Contributor

Unverified Answer

How does electronic cigarette work?

"Findings from a recent study demonstrate that e-cigarette vapor exposures are not comparable to smoke exposures in terms of cytotoxic or genotoxic exposure in human lung cell cultures. E-cigarettes were found to be an effective alternative to combustible cigarettes in terms of nicotine delivery, vaporization and nicotine cytotoxicity, as well as tobacco smoke pollution." - Anonymous Online Contributor

Unverified Answer

What is the latest research for smoking, cigarette?

"New and recent research on smoking, cigarette provides updated information on what is happening in the world of tobacco use, including smoking and smoking-related diseases. The information presented below summarizes much of the new and recent research on smoking, cigarette. In conclusion, although the long-term and negative health consequences of smoking, cigarette are well known, there are many new knowledge advances concerning the detrimental biological effects of smoking, cigarette." - Anonymous Online Contributor

Unverified Answer
Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
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