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SSRI Antidepressant

Escitalopram Combination for Depression

Phase 3
Waitlist Available
Led By Jon F. Heiser, MD
Research Sponsored by Pharmacology Research Institute
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up up to 5 years
Awards & highlights

Study Summary

This trial is testing whether combining escitalopram with another treatment is more effective, safe, and tolerable than escitalopram or the other treatment alone, or placebo, in people with major depressive disorder.

Who is the study for?
This trial is for adults with Major Depressive Disorder as defined by DSM-IV, experiencing a depressive episode lasting at least 12 weeks. It excludes those with seizure risks, pregnant or breastfeeding women not using birth control, and individuals with bipolar disorder, schizophrenia, OCD, mental retardation or developmental disorders.Check my eligibility
What is being tested?
The study tests the effectiveness of combining escitalopram with other treatments versus using it alone or a placebo in patients suffering from major depression. The goal is to see which approach works best for reducing symptoms safely and tolerably.See study design
What are the potential side effects?
Potential side effects may include nausea, sleep disturbances (like insomnia), fatigue, dry mouth, increased sweating, sexual dysfunction and weight changes. These are common side effects associated with antidepressants like escitalopram.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~up to 5 years
This trial's timeline: 3 weeks for screening, Varies for treatment, and up to 5 years for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Mental Depression
Secondary outcome measures
Hamilton Depression Rating Scale (HAMD)

Find a Location

Who is running the clinical trial?

Pharmacology Research InstituteLead Sponsor
4 Previous Clinical Trials
145 Total Patients Enrolled
1 Trials studying Depression
Jon F. Heiser, MDPrincipal InvestigatorPharmacology Research Institute
Nader Oskooilar, MDPrincipal InvestigatorPharmacology Research Institute

Media Library

Escitalopram (SSRI Antidepressant) Clinical Trial Eligibility Overview. Trial Name: NCT00239954 — Phase 3
Depression Research Study Groups:
Depression Clinical Trial 2023: Escitalopram Highlights & Side Effects. Trial Name: NCT00239954 — Phase 3
Escitalopram (SSRI Antidepressant) 2023 Treatment Timeline for Medical Study. Trial Name: NCT00239954 — Phase 3

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is this research being conducted with subjects who are over 25 years old?

"The trial's requirements state that all participants must be between 18-80 years old."

Answered by AI

Are there risks associated with this treatment method?

"There is some prior clinical data supporting the safety of this intervention, as it is a Phase 3 trial, thus it received a score of 3."

Answered by AI

Who else is applying?

What state do they live in?
California
What portion of applicants met pre-screening criteria?
Met criteria
What site did they apply to?
Pharmacology Research Institute
How many prior treatments have patients received?
3+

What questions have other patients asked about this trial?

What specifically do you require from me ?
PatientReceived 1 prior treatment
Recent research and studies
clinicaltrials.govStudy
Escitalopram Combination Comparison Study for Adult Patients With Major Depressive Disorder
2005. "Escitalopram Combination Comparison Study for Adult Patients With Major Depressive Disorder". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT00239954.
All > Mdd
~17 spots leftby Apr 2025
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