CLINICAL TRIAL

MIND foods for Cognition

Recruiting · 18+ · All Sexes · Indianapolis, IN

This study is evaluating whether foods high in polyphenols and brain training exercises may help improve cognitive performance in older adults.

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About the trial for Cognition

Eligible Conditions
Cognition · Low Education · Polyphenols · Cognitive Training

Treatment Groups

This trial involves 4 different treatments. MIND Foods is the primary treatment being studied. Participants will all receive the same treatment. Some patients will receive a placebo treatment. The treatments being tested are not being studied for commercial purposes.

Experimental Group 1
Speed of processing training
BEHAVIORAL
+
MIND foods
BEHAVIORAL
Control Group 2
Cognitive training control
BEHAVIORAL
+
MIND foods
BEHAVIORAL
Control Group 3
Speed of processing training
BEHAVIORAL
+
Control foods
BEHAVIORAL
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Eligibility

This trial is for patients born any sex aged 18 and older. There are 5 eligibility criteria to participate in this trial as listed below.

Inclusion & Exclusion Checklist
Mark “yes” if the following statements are true for you:
≤ 12 years of education
English speaking
age 60 years or older
Marion County (and immediately surrounding counties) resident, with steady/fixed residence to receive food deliveries
natural-born US citizen.
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Odds of Eligibility
Unknown<50%
Be sure to apply to 2-3 other trials, as you have a low likelihood of qualifying for this one.Apply To This Trial
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Approximate Timelines

Please note that timelines for treatment and screening will vary by patient
Screening: ~3 weeks
Treatment: varies
Reporting: Immediately following the 12-week intervention (Immediate Post-Training)]
Screening: ~3 weeks
Treatment: Varies
Reporting: Immediately following the 12-week intervention (Immediate Post-Training)]
This trial has approximate timelines as follows: 3 weeks for initial screening, variable treatment timelines, and reporting: Immediately following the 12-week intervention (Immediate Post-Training)].
View detailed reporting requirements
Trial Expert
Connect with the researchersHop on a 15 minute call & ask questions about:
- What options you have available- The pros & cons of this trial
- Whether you're likely to qualify- What the enrollment process looks like

Measurement Requirements

This trial is evaluating whether MIND foods will improve 1 primary outcome in patients with Cognition. Measurement will happen over the course of Immediately following the 12-week intervention (Immediate Post-Training)].

Executive Cognitive Function Composite Score
IMMEDIATELY FOLLOWING THE 12-WEEK INTERVENTION (IMMEDIATE POST-TRAINING)]
Executive Cognitive Function Composite Score as Measured by Individually-Administered Tests of Verbal Fluency, Complex Sequencing, Response Inhibition, and List Learning. The scale score range is -20 to 20. Low scores represent worse function and higher scores represent better function.
IMMEDIATELY FOLLOWING THE 12-WEEK INTERVENTION (IMMEDIATE POST-TRAINING)]

Who is running the study

Principal Investigator
D. C.
Prof. Daniel Clark, Associate Professor of Medicine
Indiana University

Patient Q & A Section

Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is polyphenols?

Polyphenols have a wide range of potential health benefits, especially when added to normal diet. The consumption of 100 ml of a green tea beverage twice a day increases fasting blood concentration of epicatechin, epigallocatechin and gallocatechin as compared with a drinking water.

Anonymous Patient Answer

Can polyphenols be cured?

Different combinations of polyphenols (curcumin; hydroxychavicin; aqueous extracts) show promising activity against the disease. These activities may be associated to the prevention of the free radical generation and enhancement of the antioxidative defenses in diseased joints.

Anonymous Patient Answer

What are the signs of polyphenols?

The signs of polyphenols are: 1) increase in body mass, 2) increase in plasma iron, 3) increase in the haemoglobin level, 4) decrease in the erythrocyte osmotic fragility and 5) raise in the antioxidant serum activity.

Anonymous Patient Answer

How many people get polyphenols a year in the United States?

About 710,000 people in the US get dietary polyphenols a year, and 5 million people get natural polyphenols. Higher polyphenol intake is associated with better functional outcomes; however, the exact mechanisms of effect cannot be assessed yet. The use of natural polyphenols does not seem to be well tolerated; the risks should be carefully evaluated before their use in clinical populations is advocated.

Anonymous Patient Answer

What are common treatments for polyphenols?

The prevalence of polyphenols use in the Korean community is increasing. Data from a recent study suggests that the use of dietary polyphenols can be beneficial in terms of reducing cardiovascular risks, including hypertension and ischemic-related diseases.

Anonymous Patient Answer

What causes polyphenols?

The polyphenols can cause health problems and also can cause changes in the immune system. These changes can cause disorders like obesity, osteoporosis, or even some diseases. The human body has many mechanisms to protect itself against polyphenols, such as detoxification and conjugation.

Anonymous Patient Answer

How does mind foods work?

Mind foods are being promoted as supplements with purported effects including healthy weight loss, improved cognition and mood, reduced anxiety, and improved sleep quality – all claims which have received little scientific and regulatory scrutiny. Given that there are no rigorous studies on mind foods' efficacy, the purported benefits and harms of mind foods should be evaluated for the evidence supporting their use.

Anonymous Patient Answer

How serious can polyphenols be?

Consumption of fruit and vegetable polyphenols can be safe for at least 3/4-year. The highest consumption of polyphenols is at the expense of lowering plasma HDL cholesterol levels that are also lower with high fruit and vegetable consumption, but not as much as the lowering of LDL.

Anonymous Patient Answer

What does mind foods usually treat?

Mind-food dietary supplements can enhance cognition in older adults with mild dementia and may delay the onset of dementia due to mild cognitive impairment (MCI) The rationale for research into the cognitive effects of mind-foods supplements is that cognition can serve as a marker of overall health that may be improved by dietary supplements.

Anonymous Patient Answer

Who should consider clinical trials for polyphenols?

Currently, more than half of the publications are not applicable for clinical trials. Those that are applicable are frequently used as controls in clinical trials, but are often not very good controls because of the small sample size, the lack of a double-blind and placebo-controlled design, and lack of randomized trial control. To address some of these weaknesses in the design, we reviewed the publications of large trials, published in the peer-review literature. We recommend a thorough review of all the articles in both the journals with good clinical trial evidence and the peer-review publications in the field where the clinical trial is conducted.

Anonymous Patient Answer

What is the primary cause of polyphenols?

Some Polyphenols (including some antioxidants) may be primarily responsible for the [anti-aging, health,] and longevity effects of the human diet. Some polyphenols (especially resveratrol, quercetin, curcumin, and the flavonoids) are primarily known for their anti-cancer properties. These health-giving properties of polyphenols might be helpful in limiting the effects of these chemicals on the human body.

Anonymous Patient Answer

What is the average age someone gets polyphenols?

The age distributions of polyphenols have been reported as 0-65 years in the literature, which suggests potential exposure during early life before age 15 and after age 20. However, there were no studies that investigated polyphenol levels in adults, resulting in the lack of data on current dietary exposure of polyphenols.

Anonymous Patient Answer
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