Study Summary
This trial compares low dose whole lung radiation therapy to best supportive care and physician's choice in treating patients with COVID-19 infection. Low dose whole lung radiation therapy may work better in improving patients' clinical status, the radiographic appearance of their lungs, or their laboratory blood tests.
- Symptomatic COVID-19 Infection
- Coronavirus (COVID-19)
- Pneumonia
Treatment Effectiveness
Effectiveness Progress
Study Objectives
1 Primary · 36 Secondary · Reporting Duration: Up to follow-up day 14 after study start; This may be extended to 28 days after preplanned interim analysis.
Trial Safety
Safety Progress
Trial Design
2 Treatment Groups
Arm I (physician choice)
1 of 2
Arm II (LDRT)
1 of 2
Active Control
Experimental Treatment
52 Total Participants · 2 Treatment Groups
Primary Treatment: Low Dose Radiation Therapy · No Placebo Group · Phase 3
Trial Logistics
Trial Timeline
Who is running the clinical trial?
Eligibility Criteria
Age 18+ · All Participants · 10 Total Inclusion Criteria
Mark “Yes” if the following statements are true for you:- Dhawan, Gaurav, Rachna Kapoor, Rajiv Dhawan, Ravinder Singh, Bharat Monga, James Giordano, and Edward J. Calabrese. 2020. “Low Dose Radiation Therapy as a Potential Life Saving Treatment for Covid-19-induced Acute Respiratory Distress Syndrome (ARDS)”. Radiotherapy and Oncology. Elsevier BV. doi:10.1016/j.radonc.2020.05.002.
- Lara, Pedro C., Javier Burgos, and David Macias. 2020. “Low Dose Lung Radiotherapy for COVID-19 Pneumonia. The Rationale for a Cost-effective Anti-inflammatory Treatment”. Clinical and Translational Radiation Oncology. Elsevier BV. doi:10.1016/j.ctro.2020.04.006.
- Dhawan G, Kapoor R, Dhawan R, Singh R, Monga B, Giordano J, Calabrese EJ. Low dose radiation therapy as a potential life saving treatment for COVID-19-induced acute respiratory distress syndrome (ARDS). Radiother Oncol. 2020 Jun;147:212-216. doi: 10.1016/j.radonc.2020.05.002. Epub 2020 May 8.
- Mohammad K. Khan 2020. "Best Supportive Care With or Without Low Dose Whole Lung Radiation Therapy for the Treatment of COVID-19". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT04433949.
Frequently Asked Questions
What is the most recent opinion from the FDA on Low Dose Radiation Therapy?
"Low Dose Radiation Therapy has been deemed safe by our team, as it is a Phase 3 trial. This means that there is evidence of efficacy as well as multiple rounds of data supporting safety." - Anonymous Online Contributor