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Radiation Therapy
Radiation Therapy for Non-Small Cell Lung Cancer
Phase 2
Waitlist Available
Led By Jing Zeng
Research Sponsored by University of Washington
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up at 1 year
Awards & highlights
Study Summary
This trial is testing whether PET/CT and SPECT/CT can improve radiation therapy for NSCLC patients.
Eligible Conditions
- Stage IIIB Non-Small Cell Lung Cancer
- Non-Small Cell Lung Cancer
Timeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ at 1 year
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~at 1 year
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Primary outcome measures
Overall survival (OS) rate
Secondary outcome measures
Change in pulmonary function (diffusing capacity of the lungs for carbon monoxide [DLCO])
Change in pulmonary function-forced expiratory volume in 1 second (FEV1)
Incidence of pulmonary toxicity defined as Common Terminology Criteria for Adverse Events version 4 grade 2 or higher pneumonitis
+2 moreTrial Design
1Treatment groups
Experimental Treatment
Group I: TreatmentExperimental Treatment8 Interventions
Patients undergo functional avoidance radiation therapy during weeks 1-3. Patients undergo fludeoxyglucose F-18 FDG PET/CT at baseline, 3 weeks, and 3 months post-radiation therapy and undergo technetium Tc-99m albumin aggregated (99mTc-MAA) and technetium Tc-99m sulfur colloid SPECT/CT radiation therapy at baseline and 3 months post-radiation therapy. Baseline PET/CT must be performed at University of Washington Medical Center/Seattle Cancer Care Alliance and be within one month of treatment start, therefore some patients may need to repeat a baseline PET/CT if their PET/CT is from an outside institution or > 1 month old. Patients not responding to treatment at 3 weeks, will receive an increased daily radiation therapy dosage.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Radiation Therapy
2017
Completed Phase 3
~7250
Technetium Tc-99m Albumin Aggregated
2014
Completed Phase 2
~70
Single Photon Emission Computed Tomography
2008
Completed Phase 4
~310
Technetium Tc-99m Sulfur Colloid
2016
Completed Phase 2
~160
Computed Tomography
2017
Completed Phase 2
~2720
Fludeoxyglucose F-18
2018
Completed Phase 2
~550
Positron Emission Tomography
2008
Completed Phase 2
~2240
Find a Location
Who is running the clinical trial?
University of WashingtonLead Sponsor
1,741 Previous Clinical Trials
1,847,710 Total Patients Enrolled
National Cancer Institute (NCI)NIH
13,672 Previous Clinical Trials
40,926,385 Total Patients Enrolled
Jing ZengPrincipal InvestigatorFred Hutch/University of Washington Cancer Consortium
7 Previous Clinical Trials
54 Total Patients Enrolled
Media Library
Eligibility Criteria:
This trial includes the following eligibility criteria:- You are currently receiving chemotherapy treatment.You have lost more than 10% of your body weight in the past month without trying to.
Research Study Groups:
This trial has the following groups:- Group 1: Treatment
Awards:
This trial has 1 awards, including:- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
Timeline:
This trial has the following timeline:- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Are people still able to join this experiment?
"Unfortunately, this specific trial is no longer recruiting patients, as reflected on clinicaltrials.gov. The trial was originally posted on May 20th 2016 and was last updated on July 18th 2022. Although this study is not taking any more participants, there are 1,397 other trials that are still looking for candidates."
Answered by AI
What are the government's thoughts on Radiation Therapy?
"While Phase 2 trials don't have the same level of data supporting efficacy, there is some clinical evidence for the safety of Radiation Therapy. For this reason, our team at Power estimates its safety to be a 2."
Answered by AI
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