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Radiation Therapy

V/Q SPECT for Non-Small Cell Lung Cancer

N/A

Waitlist Available

Led By Shruti Jolly, M.D.

Research Sponsored by University of Michigan Rogel Cancer Center

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up up to 60 months

Awards & highlights

Study Summary

This trial is designed to see if using a PET scan and a perfusion scan before and during radiation therapy for lung cancer helps to predict how well the treatment works and how well the lung functions during treatment.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ up to 60 months

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~up to 60 months

This trial's timeline: 3 weeks for screening, Varies for treatment, and up to 60 months for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Comparison of delivered dose to dose that would have been administered using the criteria described in protocol UMCC 2007.123 (NCT01190527)

The number of patients for whom treatment is feasible.

The number of patients that experience grade 2 or greater esophageal toxicity

+1 more

Secondary outcome measures

Overall survival time

Time to local progression

Trial Design

1Treatment groups

Experimental Treatment

Group I: Response-driven Adaptive RTExperimental Treatment6 Interventions

Patients will receive treatment 5 days per week, in once daily fractions, for 30 treatments with dose per fraction individually adapted over the final 9 treatments. Patients may also receive concurrent chemotherapy with Carboplatin and Paclitaxel. Patients may receive consolidation chemotherapy (carboplatin and paclitaxel) or immunotherapy (durvalumab) at the discretion of the medical oncologist.

Treatment

First Studied

Drug Approval Stage

How many patients have taken this drug

FDG-PET

2008

Completed Phase 4

~600

Paclitaxel

2011

Completed Phase 4

~5380

V/Q SPECT

2016

N/A

~50

Durvalumab

2017

Completed Phase 2

~3870

Response-driven Adaptive Radiation Therapy

2016

N/A

~50

Carboplatin

2014

Completed Phase 3

~6670

Do I qualify?Apply below to find out

Find a Location

Who is running the clinical trial?

University of Michigan Rogel Cancer CenterLead Sponsor

293 Previous Clinical Trials

24,048 Total Patients Enrolled

Shruti Jolly, M.D.Principal InvestigatorUniversity of Michigan Rogel Cancer Center

3 Previous Clinical Trials

190 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What prior experimentation has been conducted with V/Q SPECT?

"Currently, there exist 1435 studies exploring the efficacy of V/Q SPECT. Of these trials, 365 are in Phase 3 development and 74833 sites across Shanghai are hosting them."

Answered by AI

How many participants are currently being accepted for this research trial?

"Unfortunately, this research project has closed its doors to new participants. The trial was first uploaded on January 14th 2016 and the latest update happened on December 17th 2021. If you are seeking other trials, there are 1365 studies for carcinoma non-small cell lung cancer patients actively recruiting and 1435 V/Q SPECT clinical trials searching for volunteers."

Answered by AI

How is V/Q SPECT customarily deployed in clinical practice?

"V/Q SPECT has traditionally been used for palliative care, but it can also be employed to treat a range of medical conditions such as malignant peritoneal neoplasm in newly diagnosed patients."

Answered by AI

Are there available slots for participants in this clinical trial?

"This clinical trial, initially posted on January 14th 2016 and last updated December 17th 2021 is no longer recruiting according to the data hosted by clinicaltrials.gov. Nonetheless, there are presently 2,800 other medical studies actively seeking out participants."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

A Pilot Study of Response-Driven Adaptive Radiation Therapy for Patients With Locally Advanced Non-Small Cell Lung Cancer

2016. "A Pilot Study of Response-Driven Adaptive Radiation Therapy for Patients With Locally Advanced Non-Small Cell Lung Cancer". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT02492867.