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Opioid Analgesic

Patient-Specific Protocol for Sickle Cell Disease (COMPARE-VOE Trial)

Phase 3
Waitlist Available
Led By Huiman Barnhart, PhD
Research Sponsored by Duke University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up up to 7 days post enrollment
Awards & highlights

COMPARE-VOE Trial Summary

This study is evaluating whether a weight-based or patient-specific approach to pain management is more effective for individuals with sickle cell disease.

Eligible Conditions
  • Sickle Cell Disease

COMPARE-VOE Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~up to 7 days post enrollment
This trial's timeline: 3 weeks for screening, Varies for treatment, and up to 7 days post enrollment for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
The Change in Pain Score
Secondary outcome measures
Length of Care
Length of Index ED (Emergency Department) Stay
Number of Participants Experiencing Side Effects
+1 more

COMPARE-VOE Trial Design

2Treatment groups
Experimental Treatment
Group I: Weight-based ProtocolExperimental Treatment3 Interventions
Patients assigned to this treatment protocol will be given pain medicine(s) based on their weight.
Group II: Patient-Specific ProtocolExperimental Treatment3 Interventions
Patients assigned to this treatment protocol will be given pain medicine(s) based on the pain medicine(s) they take at home, what was needed during their past hospital and emergency department visits to treat pain and doses that have been effective and safe in the past.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Hydromorphone
2005
Completed Phase 4
~4340
Morphine
2013
Completed Phase 4
~2230

Find a Location

Who is running the clinical trial?

Duke UniversityLead Sponsor
2,363 Previous Clinical Trials
3,420,158 Total Patients Enrolled
National Heart, Lung, and Blood Institute (NHLBI)NIH
3,838 Previous Clinical Trials
47,851,326 Total Patients Enrolled
Huiman Barnhart, PhDPrincipal InvestigatorDuke University

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
clinicaltrials.govStudy
Comparing Individualized vs. Weight Based Protocols to Treat Vaso-Occlusive Episodes in Sickle Cell Disease
2019. "Comparing Individualized vs. Weight Based Protocols to Treat Vaso-Occlusive Episodes in Sickle Cell Disease". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT03933397.
~58 spots leftby Apr 2025
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