TCRαβ+/CD19+ depleted allogeneic hematopoietic stem cell transplant (HSCT) for Bone Marrow Transplant

Cincinnati Children's Hospital Medical Center, Cincinnati, OH
Bone Marrow TransplantTCRαβ+/CD19+ depleted allogeneic hematopoietic stem cell transplant (HSCT) - Drug
Eligibility
Any Age
All Sexes

Study Summary

This trial is testing whether a new way to do a stem cell transplant, which uses a device to remove some cells from the transplanted blood, is safe and effective in children and young adults with cancer or other blood disorders.

Treatment Effectiveness

Study Objectives

1 Primary · 4 Secondary · Reporting Duration: 1 year

1 year
GVHD-free survival
Incidence of chronic GVHD
100 days
Incidence of acute GVHD
Incidence of infusion-related reactions
Year 1
Engraftment and Sustained Donor Chimerism

Trial Safety

Phase-Based Safety

2 of 3
This is further along than 68% of similar trials

Awards & Highlights

No Placebo Group
All patients enrolled in this trial will receive the new treatment.

Trial Design

1 Treatment Group

TCRαβ+/CD19+ depleted HSCT
1 of 1

Experimental Treatment

80 Total Participants · 1 Treatment Group

Primary Treatment: TCRαβ+/CD19+ depleted allogeneic hematopoietic stem cell transplant (HSCT) · No Placebo Group · Phase 2

TCRαβ+/CD19+ depleted HSCT
Drug
Experimental Group · 1 Intervention: TCRαβ+/CD19+ depleted allogeneic hematopoietic stem cell transplant (HSCT) · Intervention Types: Drug

Trial Logistics

Trial Timeline

Screening: ~3 weeks
Treatment: Varies
Reporting: 1 year

Who is running the clinical trial?

Children's Hospital Medical Center, CincinnatiLead Sponsor
772 Previous Clinical Trials
5,424,848 Total Patients Enrolled

Eligibility Criteria

Age Any Age · All Participants · 0 Total Inclusion Criteria

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Frequently Asked Questions

Are there any opportunities to enroll in this medical trial currently available?

"This trial, which has been advertised since September 16th 2019 and recently updated on the 21st of September 2021, is now actively seeking participants." - Anonymous Online Contributor

Unverified Answer

To what extent is TCRαβ+/CD19+ depleted allogeneic hematopoietic stem cell transplant (HSCT) a safe procedure for people?

"The safety of TCRαβ+/CD19+ depleted allogeneic hematopoietic stem cell transplant (HSCT) was assessed as a 2, since there is preliminary data that suggests its safety but no evidence to back efficacy." - Anonymous Online Contributor

Unverified Answer

What is the current aggregate of participants in this medical experiment?

"Correct. According to the information posted on clinicaltrials.gov, this study is actively seeking participants with an initial posting date of September 16th 2019 and a recent update as of September 21st 2021. 80 patients must be enrolled from one medical site for the trial to move forward." - Anonymous Online Contributor

Unverified Answer
Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.