TPX-0005 for Cancer
This study is evaluating whether a drug called Repotrectinib can be used to treat people with advanced cancer.
See full descriptionAbout the trial for Cancer
Treatment Groups
This trial involves 2 different treatments. TPX-0005 is the primary treatment being studied. Participants will all receive the same treatment. There is no placebo group. The treatments being tested are in Phase 1 & 2 and have already been tested with other people.
About The Treatment
Eligibility
This trial is for patients born any sex aged 18 and older. There are 7 eligibility criteria to participate in this trial as listed below.
Approximate Timelines
Measurement Requirements
This trial is evaluating whether TPX-0005 will improve 3 primary outcomes and 8 secondary outcomes in patients with Cancer. Measurement will happen over the course of Up to 24 hours post-dose.
Patient Q & A Section
What are common treatments for cancer?
Patients and their family caregivers are asked to identify what treatments are most used or being used for cancer from a list of treatments, and this is then presented to all patients. Some patients receive the option of refusing certain treatments or palliative care, but for the rest of the treatment, the most commonly used treatment is given.
How many people get cancer a year in the United States?
There will be nearly 1,800,000 new cancer diagnoses that will be made in the US in 2019 alone. The total estimated number of new cancers a year in the U.S. in 2019 is estimated at 7.5 million cancers.
What is cancer?
Cancer is an illness of the cell that often affects and destroys the cells in the tissue by an immune and/or cytotoxic effect. More than 20 million people will be diagnosed with cancer at some point in their life, and roughly half of cases will be diagnosed during adulthood. We can live forever if diagnosed early and adequately treated. Cancer is now the second leading cause of death in Canada, after heart disease.
What are the signs of cancer?
The most significant symptom of cancer is unexplained weight loss. Other signs include unexplained cough, chest pain, dyspnea, and unexplained fatigue. Other symptoms, such as the cough of pleuritic chest pain are not typically found to be associated with cancer. In patients with signs of malignancy, CT scan is typically ordered. A history of smoking and alcohol consumption should be obtained as well. For patients with unexplained cancer-associated fatigue and weight loss, a diagnosis of inflammatory demyelinating polyneuropathies should be considered. Patients with unexplained neurologic deficit are often found to have leukemia.
What causes cancer?
There are many possible causes of cancer. There is evidence that smoking is the best understood cause. Cancer is a disease of accumulated cellular changes in body cells and the cancer process starts when a mutated gene causes cancer. Some mutations are inherited but most arise in normal cells after some form of stress induces cellular changes in the normal cell DNA.\n\nWhen a cancer starts, there's often a change in the rate of cell division or the way cells divide. The tumor is made up of a group of cells with abnormal cell division that often causes it to invade or spread to other parts of the body. Different types of cancers are caused at different locations at different times. Cancer in the brain occurs in cancer of the neurons in the brain.
Can cancer be cured?
In summary, the research indicates that a cure for most forms of cancer is highly unlikely and this view is supported by the evidence cited.
Have there been any new discoveries for treating cancer?
For the past few decades, cancer treatment has been dominated by radiation and chemotherapy. Recently, we have witnessed more focus and progress in the fields of biology, genetics, genomics, immunology, surgery, and oncology of the disease. It seems that cancer treatment is going in the right direction nowadays but there are still many challenges on how to treat cancer with the best chance of cure. What follows is a look at current developments in cancer treatment that we hope will eventually reach curing cancer.
Who should consider clinical trials for cancer?
Clinical trials for cancer should be conducted by a clinical oncologist for early phase of the disease as most of the cancers have a favorable response in early phase. Clinical trials can be safely administered by a oncology resident for advanced phase of the disease.
How does tpx-0005 work?
When the tpx-0005 was administered to mice that had been subjected to X-Ray radiation and/or chemical compounds that had a therapeutic effect on the human cancerous cells, these mice seemed to tolerate tpx-0005 better than the individuals who had not had these treatments. The increased number of mature dendritic cells in the lung tissues of the irradiated tpx-0005-treated mice indicates their better ability to reject tumors in those lungs. Data from a recent study encourage further efforts to evaluate tpx-0005's potential role as an immunomodulator in cancer, particularly as a method of reversing immunosuppressive mechanisms in the tumor microenvironment that may lead to enhanced anticancer treatment success.
What does tpx-0005 usually treat?
We were surprised that both breast and colorectal cancers frequently manifest in the lungs. We found that tpx-0005 could treat lung complaints on a regular basis. This treatment is not in its current form.