Study Summary
This trial will help researchers learn more about how to help people who have lost their sense of smell due to COVID-19.
- Loss of Smell
- Anosmia
- Coronavirus
Treatment Effectiveness
Effectiveness Progress
Study Objectives
1 Primary · 6 Secondary · Reporting Duration: Baseline and 6 months after initial consult appointment
Trial Safety
Safety Progress
Trial Design
2 Treatment Groups
Smell Retraining Only
1 of 2
Smell Retraining + Budesonide
1 of 2
Active Control
Experimental Treatment
60 Total Participants · 2 Treatment Groups
Primary Treatment: Smell Retraining · No Placebo Group · Phase 1 & 2
Trial Logistics
Trial Timeline
Who is running the clinical trial?
Eligibility Criteria
Age 6 - 21 · All Participants · 2 Total Inclusion Criteria
Mark “Yes” if the following statements are true for you:Who else is applying?
What state do they live in?
| Texas | 40.0% |
| South Carolina | 20.0% |
| New Mexico | 20.0% |
| Other | 20.0% |
How old are they?
| 18 - 65 | 75.0% |
| 65+ | 25.0% |
What portion of applicants met pre-screening criteria?
| Did not meet criteria | 100.0% |
Why did patients apply to this trial?
- "I'm a chef who has only been able to smell 3-4 times in the last 18 months, and only for 1 minute increments."
- "I lost my sense of smell at the end of having Covid in May. It went completely. I went on steroids and it came back, but within days of finishing my course of steroids it went away again. It differs day to day - sometimes I can faintly smell my coffee, others not at all. I had a hypersensitive sense of smell before and I hate not being able to smell."
How many prior treatments have patients received?
| 0 | 50.0% |
| 2 | 50.0% |
What site did they apply to?
| UPMC Children's Hospital of Pittsburgh | 100.0% |
What questions have other patients asked about this trial?
- "My financial situation has significantly worsened due to anosmia. Are the costs associated with trips to the hospital for the study offset?"
Frequently Asked Questions
Are people of all ages eligible for this clinical trial?
"Researchers are looking for participants who were born between 1999 and 2006." - Anonymous Online Contributor
What are the screening procedures for this test?
"The ideal participant for this clinical trial is a child or young adult aged 6-21 who currently suffers from anosmia. Additionally, it is imperative that potential subjects are able to take the UPSIT smell test, self-report any changes in their sense of smell, and commit to the assigned daily therapy." - Anonymous Online Contributor
For what purpose is Smell Retraining therapy most often used?
"Smell Retraining is a conventional medical intervention used to treat acute coryza. However, it can also be used in less common cases such as when patients suffer from proteinuria or Crohn disease." - Anonymous Online Contributor
How many people have been invited to participate in this research project?
"The latest information from clinicaltrials.gov suggests that this research study is still looking for participants. The 60 patients will be recruited from a single site, and the trial was first posted on September 30th, 2021." - Anonymous Online Contributor
Could you share some other studies that have used Smell Retraining?
"At present, there are 32 separate studies being conducted on smell retraining. 10 of those studies are in phase 3 clinical trials. Most of the trials for smell retraining are taking place in Xi'an, Shaanxi, but there are 992 locations around the world where these trials are being run." - Anonymous Online Contributor
Can patients still enroll in this experiment?
"Yes, the information available on clinicaltrials.gov verifies that this trial is still recruiting patients. This particular study was opened on September 30th, 2021 and was last updated October 5th, 2022. The research team is looking for 60 participants total from 1 location." - Anonymous Online Contributor