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Mineral Supplement

Magnesium Citrate plus probiotic for Coronavirus Disease (CHANGE Trial)

Phase 1 & 2
Waitlist Available
Research Sponsored by Vanderbilt University Medical Center
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up baseline and 7 days
Awards & highlights

Summary

This trial is testing whether magnesium citrate combined with a probiotic can help treat adults hospitalized with COVID-19.

Eligible Conditions
  • Coronavirus Disease

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~baseline and 7 days
This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline and 7 days for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
COVID Ordinal Outcome Scale
Secondary outcome measures
Change in Oxygen Requirements From Baseline to Day 7 by Treatment Group

Trial Design

2Treatment groups
Experimental Treatment
Placebo Group
Group I: Magnesium Citrate plus a Probiotic Arm:Experimental Treatment1 Intervention
Participants assigned to the magnesium citrate plus a probiotic arm will receive 1 bottle of magnesium citrate 296 mL PO once to be taken within a 4-hour period, (about 10 oz.). Because magnesium citrate remains within the intestinal lumen, a second bottle can be provided if there is limited bowel movement. Patients will be asked to take 2 capsules of probiotics twice daily for six days or until discharge, whichever is earlier.
Group II: PlaceboPlacebo Group1 Intervention
Participants randomized to the placebo arm will receive matching placebo 296 mL PO once to be taken within a 4-hour period, (about 10 oz.) and 2 cellulose capsules twice daily for six days or until discharge, whichever is earlier. The placebo will be flavored to match the taste of the interventional arm.

Who is running the clinical trial?

Vanderbilt University Medical CenterLead Sponsor
869 Previous Clinical Trials
678,601 Total Patients Enrolled
~6 spots leftby Jul 2025