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Probiotic

Probiotics for Long COVID Symptoms

N/A
Recruiting
Led By Michael E Widlansky, MD, MPH
Research Sponsored by Medical College of Wisconsin
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
30-180 days post-COVID-19 diagnosis
Ages 18 to 89 years
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 8 weeks
Awards & highlights

Study Summary

This trial will test whether the probiotic Lactobacillus plantarum 299v can help reduce symptoms in people who have already had COVID-19.

Who is the study for?
This trial is for adults aged 18-89 who have had COVID-19 and are experiencing lingering symptoms known as PASC. They must be within 30 to 180 days post-diagnosis. People with daily alcohol use, recent antibiotics, blood thinner usage like warfarin, pregnancy, cognitive issues preventing study compliance, unstable heart disease or certain chronic conditions can't participate.Check my eligibility
What is being tested?
The trial tests if a probiotic called Lactobacillus plantarum (Lp299v) in capsule form can improve blood vessel function in those with PASC by reducing inflammation and immune system activation compared to a placebo made of potato starch capsules.See study design
What are the potential side effects?
While the specific side effects aren't listed here, probiotics like Lp299v typically may cause digestive discomfort such as gas or bloating. Placebos generally have no active ingredients but can sometimes cause mild reactions due to psychological factors.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
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I was diagnosed with COVID-19 between 30 to 180 days ago.
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I am between 18 and 89 years old.
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I am between 18 and 89 years old.
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I have been diagnosed with long COVID by a doctor.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~8 weeks
This trial's timeline: 3 weeks for screening, Varies for treatment, and 8 weeks for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Brachial Artery Flow Mediated Dilation (FMD%)
Secondary outcome measures
Brachial Artery Resting Diameter
Carotid-Femoral Pulse Wave Velocity (cfPWV)
Cell-Free Mitochondrial DNA (cf-mtDNA)
+7 more

Trial Design

2Treatment groups
Experimental Treatment
Placebo Group
Group I: Lp299vExperimental Treatment1 Intervention
Subjects will consume 20 billion colony forming units of Lp299v (2 capsules) once daily for 8 weeks.
Group II: Heat-killed placebo controlPlacebo Group1 Intervention
Subjects will consume potato starch (2 capsules) once daily for 8 weeks.

Find a Location

Who is running the clinical trial?

Medical College of WisconsinLead Sponsor
608 Previous Clinical Trials
1,162,431 Total Patients Enrolled
6 Trials studying COVID-19
533 Patients Enrolled for COVID-19
Michael E Widlansky, MD, MPHPrincipal InvestigatorMedical College of Wisconsin
2 Previous Clinical Trials
43 Total Patients Enrolled

Media Library

Lp299v (Probiotic) Clinical Trial Eligibility Overview. Trial Name: NCT05227170 — N/A
COVID-19 Clinical Trial 2023: Lp299v Highlights & Side Effects. Trial Name: NCT05227170 — N/A
COVID-19 Research Study Groups: Lp299v, Heat-killed placebo control
Lp299v (Probiotic) 2023 Treatment Timeline for Medical Study. Trial Name: NCT05227170 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is the cap on participant enrollment for this clinical experiment?

"Affirmative, information on clinicaltrials.gov demonstrates that this medical trial is actively looking for participants, beginning April 29th 2022 and most recently updated June 22nd 2022. 80 individuals are sought after at a single site."

Answered by AI

Are adults eligible to participate in the experiment?

"This clinical trial seeks volunteers aged 18 and over, but not exceeding 89 years of age."

Answered by AI

What are the ideal characteristics of participants for this research project?

"Candidates must fulfill two requirements to be admitted into this covid-19 trial: they should possess the virus and their age should range from 18 to 89. The medical study is looking for about 80 participants in total."

Answered by AI

Are participants currently being welcomed into this research study?

"This clinical trial is currently looking for volunteers, having been first posted on April 29th 2022 and last updated June 22nd 2022. The information can be found at clinicaltrials.gov."

Answered by AI

Who else is applying?

What state do they live in?
Ohio
How old are they?
18 - 65
What site did they apply to?
Medical College of Wisconsin
What portion of applicants met pre-screening criteria?
Met criteria

How responsive is this trial?

Typically responds via
Email
Most responsive sites:
  1. Medical College of Wisconsin: < 24 hours
Average response time
  • < 1 Day
~27 spots leftby Mar 2025