CLINICAL TRIAL

Executive function group therapy for Autism Spectrum Disorder

Recruiting · < 65 · All Sexes · Washington, United States

Intervention-Induced Plasticity of Flexibility and Learning Mechanisms in ASD

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About the trial for Autism Spectrum Disorder

Eligible Conditions
Autism Spectrum Disorder · Adolescent Behaviors · Executive Dysfunction

Treatment Groups

This trial involves 2 different treatments. Executive Function Group Therapy is the primary treatment being studied. Participants will all receive the same treatment. There is no placebo group. The treatments being tested are not being studied for commercial purposes.

Main TreatmentA portion of participants receive this new treatment to see if it outperforms the control.
Executive function group therapy
BEHAVIORAL
Control TreatmentAnother portion of participants receive the standard treatment to act as a baseline.

Eligibility

This trial is for patients born any sex aged 65 and younger. There are 5 eligibility criteria to participate in this trial as listed below.

Inclusion & Exclusion Checklist
Mark “yes” if the following statements are true for you:
The individual has a Full scale IQ (FSIQ) of 80 or greater on a standardized IQ test, either confirmed through educational testing within the last two years or confirmed by the Wechsler Abbreviated Scale of Intelligence (WASI-2) administered by research personnel show original
The study found that a broad autism spectrum diagnosis according to DSM-5 criteria can be established by parent report of a prior clinical diagnosis and confirmed by meeting cutoff criteria on the Social Communication Questionnaire (SCQ) or the Autism Diagnostic Observation Schedule-2 (ADOS-2), Module 4. show original
People aged 14-18 are included in this group. show original
Someone who has good hearing and vision, or who has had their hearing or vision corrected, is said to have intact or corrected hearing and vision. show original
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Odds of Eligibility
Unknown<50%
Be sure to apply to 2-3 other trials, as you have a low likelihood of qualifying for this one.Apply To This Trial
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Approximate Timelines

Please note that timelines for treatment and screening will vary by patient
Screening: ~3 weeks
Treatment: varies
Reporting: 8-12 months before intervention, at start of intervention, 8-12 months after intervention begins
This trial has approximate timelines as follows: 3 weeks for initial screening, variable treatment timelines, and reporting: 8-12 months before intervention, at start of intervention, 8-12 months after intervention begins.
View detailed reporting requirements
Trial Expert
Connect with the researchersHop on a 15 minute call & ask questions about:
- What options you have available- The pros & cons of this trial
- Whether you're likely to qualify- What the enrollment process looks like

Measurement Requirements

This trial is evaluating whether Executive function group therapy will improve 2 primary outcomes, 1 secondary outcome, and 11 other outcomes in patients with Autism Spectrum Disorder. Measurement will happen over the course of 8-12 months before intervention, at start of intervention, 8-12 months after intervention begins.

Change in CVLT-C Scores
8-12 MONTHS BEFORE INTERVENTION, AT START OF INTERVENTION, 8-12 MONTHS AFTER INTERVENTION BEGINS
California Verbal Learning Test Children's Version (CVLT-C) is used to assess verbal learning and memory through an everyday memory task in which the child is asked to recall a list. The measure is for children and adolescents 5 through 16.11 years
Change in Flexibility Scale Scores
8-12 MONTHS BEFORE INTERVENTION, AT START OF INTERVENTION, 8-12 MONTHS AFTER INTERVENTION BEGINS, 8-12 MONTHS AFTER INTERVENTION ENDS
The Flexibility Scale (FS) is a 27-item measure assessing five categories related to flexibility: routines and rituals, transitions/change, special interests, social flexibility and generativity
Change in CVLT-3 Scores
8-12 MONTHS BEFORE INTERVENTION, AT START OF INTERVENTION, 8-12 MONTHS AFTER INTERVENTION BEGINS
California Verbal Learning Test Adolescent and Adult Version (CVLT-3) is used to assess verbal learning and memory through an everyday memory task in which the individual is asked to recall a list. The measure is for Individuals between 16-90 years old
Change in PRAS-ASD Scores
8-12 MONTHS BEFORE INTERVENTION, AT START OF INTERVENTION, 8-12 MONTHS AFTER INTERVENTION BEGINS, 8-12 MONTHS AFTER INTERVENTION ENDS
Parent-Rated Anxiety Scale for Autism Spectrum Disorder (PRAS-ASD) is 25-item measure for anxiety. This is a reliable and valid measure that can be used to assess severity of anxiety in youth with ASD and evaluate change with treatment
Change in BDI-II Scores
8-12 MONTHS BEFORE INTERVENTION, AT START OF INTERVENTION, 8-12 MONTHS AFTER INTERVENTION BEGINS, 8-12 MONTHS AFTER INTERVENTION ENDS
The Beck Depression Inventory (BDI) is a 21-item, self-report rating inventory that measures characteristic attitudes and symptoms of depression
Change in Rey Complex Figure Test and Recognition Trial Scores
8-12 MONTHS BEFORE INTERVENTION, AT START OF INTERVENTION, 8-12 MONTHS AFTER INTERVENTION BEGINS
Rey Complex Figure Test and Recognition Trial (RCFT) tests visuospatial constructional ability and visuospatial memory using the "complex figure." The RCFT consists of four separate tasks and is scored using specific criteria developed for scoring the accuracy and placement of individual units of the complex figure
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Who is running the study

Principal Investigator
L. K.
Lauren Kenworthy, ASSOC CHIEF NEUROPSYCHOLOGY
Children's National Research Institute

Patient Q & A Section

Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What are common treatments for adolescent behaviors?

This was a comprehensive review of treatment-type effectiveness research in adolescent behavior interventions. The quality and quantity of information was relatively high, with a focus on high quality randomized controlled trials; however, some of the studies were not powered and had relatively low methodological quality. Although the majority of studies were statistically powerful and generally effective, the results of this review do suggest that treatments based on empirical research that are designed to treat both internalizing and externalizing behaviours might not always be effective in decreasing these problems in adolescents.

Anonymous Patient Answer

What causes adolescent behaviors?

Adolescent behaviors are influenced by many factors such as gender, age, ethnicity and cultural values. Most of these factors are influenced by biological as well as environmental factors. More research should be done to identify the environmental determinants of adolescent behavior. Understanding these factors could help us in designing appropriate interventions to reduce the risk of adolescent behavior.

Anonymous Patient Answer

How many people get adolescent behaviors a year in the United States?

Although there are differences in rates of adolescent behaviors across the United States' adolescent population, there is a large variation in rates, with an average of approximately 200 behaviors per youth in some areas but only 7 behaviors per youth in other areas. Overall, youth in U.S. states that typically have low rates of adolescent behaviors do not have more than 1.4 adolescent behaviors a year for females and 0.8 adolescent behaviors a year for males, which is comparable with similar rates among their peers in other developed countries.

Anonymous Patient Answer

Can adolescent behaviors be cured?

In a recent study, findings of this study show that adolescent behavior can be improved to the point that it can have a significant impact on the future well-being of a teen.

Anonymous Patient Answer

What is adolescent behaviors?

Understanding adolescent behavior needs to be integrated into adolescent counseling. This article is a call for clinicians, parents, and educators to be mindful, positive, and sensitive with adolescents when discussing topics such as sexuality and drugs.

Anonymous Patient Answer

What are the signs of adolescent behaviors?

These disorders can occur independently of serious mental illness but may contribute to poor adjustment to peer pressure and increased dependence on medications for anxiety and substance use.

Anonymous Patient Answer

What is executive function group therapy?

Executive function group therapy has been shown to be successful in alleviating symptoms associated with ADHD in children and adults. Executive function group therapy may be an effective treatment to reduce symptoms associated with ADHD in adults.

Anonymous Patient Answer

What is the latest research for adolescent behaviors?

Adolescent behavior can relate broadly to health, especially to life in the social world, but also to experiences in the personal world. A growing body of research suggests that behavior can be studied as a function of an individual’s context as well as a biological-behavioral-social-economic context (e.g. social capital, peer context). Research is needed on the developmental relationships between adolescent behaviors and adolescent health and contextual factors (e.g. socioeconomic context) that influence how adolescent behaviors are interpreted, experienced, and acted upon.

Anonymous Patient Answer

Who should consider clinical trials for adolescent behaviors?

Results from a recent clinical trial have important clinical implications for clinicians as well as parents whose younger children have not yet begun to engage in problem behaviors.

Anonymous Patient Answer

Is executive function group therapy typically used in combination with any other treatments?

Executive function group training is used as a treatment to target executive dysfunction in a range of clinical conditions. There is a substantial empirical record of its use in adolescent clinical settings for ADHD. However, executive function group training is not typically used in combination with treatment for other childhood emotional or behavioral disorders, and only a handful of trials exist for treatment for adult executive dysfunction. These data highlight the need for more study of the use of this approach in a wide range of situations, with more attention to optimizing treatment protocols and assessing whether interventions are effective.

Anonymous Patient Answer

How serious can adolescent behaviors be?

Findings from this investigation indicate that adolescents have the ability to engage in risky behaviors that can, with proper parenting, lead to serious health consequences. The most effective and cost-effective method for preventing adolescent risky behavior would be to decrease the number of adolescent-young adolescent interactions.

Anonymous Patient Answer

What are the latest developments in executive function group therapy for therapeutic use?

Findings suggest that the majority of EF group therapies in use in the United States were developed before 2000. They also suggest that most used a group of at least five EF subtypes.

Anonymous Patient Answer
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