82 Participants Needed

Low vs Standard Pressure for Postoperative Pain

(LOw PRESSuRE Trial)

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MS
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Overseen BySara Hojabri, MBBCHBAO
Age: 18+
Sex: Female
Trial Phase: Academic
Sponsor: Mount Sinai Hospital, Canada
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

What You Need to Know Before You Apply

What is the purpose of this trial?

This proposed study is a single-center, double blind, parallel group RCT comparing the use of low (10 mm Hg) versus standard pressure (15 mm Hg) pneumoperitoneum at the time of benign gynecologic laparoscopic surgery. Patients will be randomized to the control group (standard pressure) or the intervention group (low pressure) and surgeons will be blinded to the study pressure. Data on post-operative recovery and pain scores will be recorded for each patient.

Are You a Good Fit for This Trial?

This trial is for individuals undergoing certain benign gynecologic surgeries, such as removal of ovaries or ovarian cysts. Participants must understand and sign the consent form, be able to follow study procedures, and have the capacity to provide informed consent.

Inclusion Criteria

Participant must sign and date the informed consent form
I am 18 years old or older.
I understand the details of the clinical trial and can make decisions about my care.
See 2 more

Exclusion Criteria

I experience chronic pain.
My gynecological cancer is stage 2 or beyond.
Language barrier
See 5 more

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

1 day
1 visit (in-person)

Treatment

Participants undergo laparoscopic gynecologic surgery with either low or standard pressure pneumoperitoneum

1 day
1 visit (in-person)

Post-operative Monitoring

Post-operative pain, nausea, and medication use are assessed in the PACU. Patients are contacted on POD1 to assess post-operative pain scores and adverse events.

1 day
1 visit (in-person), 1 follow-up call

Follow-up

Participants are monitored for safety and effectiveness after treatment, including assessment of pain and recovery scores

1 day
1 follow-up call

What Are the Treatments Tested in This Trial?

Interventions

  • Low Pressure Pneumoperitoneum
Trial Overview The study compares low (10 mm Hg) versus standard pressure (15 mm Hg) pneumoperitoneum during laparoscopic surgery. It's a double-blind trial where patients are randomly assigned to either control (standard pressure) or intervention (low pressure).
How Is the Trial Designed?
2Treatment groups
Experimental Treatment
Active Control
Group I: Low PressureExperimental Treatment1 Intervention
Patients undergoing experimental intervention of low pressure pneumoperitoneum (10 mm Hg)
Group II: Standard PressureActive Control1 Intervention
Patients undergoing laparosocpy at standard pressure (15 mm Hg)

Find a Clinic Near You

Who Is Running the Clinical Trial?

Mount Sinai Hospital, Canada

Lead Sponsor

Trials
210
Recruited
70,700+

Women's College Hospital

Collaborator

Trials
108
Recruited
43,700+
Unbiased ResultsWe believe in providing patients with all the options.
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