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CIML-NK Cells for Acute Myeloid Leukemia
Study Summary
This trial tests if donor-derived memory-like NK cells can be safely infused to fight relapsed/refractory AML, to see if they are effective in treating the disease.
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowTimeline
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Trial Design
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Who is running the clinical trial?
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- My heart's pumping ability is below 45%.My leukemia did not respond well to initial treatments.I am 12 years old or older.I do not have any active, uncontrolled infections.I have a closely related donor who is a partial genetic match for me.I have been diagnosed with acute myeloid leukemia.My leukemia has returned within 6 months after initial remission.I can do most activities or chores without help, regardless of my age.My AML has returned or didn't respond to treatment.I am taking less than 10mg of prednisone or its equivalent daily.My kidney function is reduced, with a GFR less than 50 mL/min.My condition is either CNS disease, extramedullary disease, or APML.My liver tests are not within the normal range.I am not pregnant or breastfeeding and will use effective birth control during and after the study.
- Group 1: Cytokine-Induced Memory-Like Natural Killer (CIML-NK) Cells
- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
How many volunteers have signed up for this research endeavor?
"Yes, according to the data on clinicaltrials.gov this research is actively seeking volunteers. First posted on December 1st 2022 and most recently updated on November 30th 20202, 20 people are needed from a single location for enrolment in this study."
Is enrollment for this research experiment still open?
"Affirmative. Information posted on clinicaltrials.gov suggests that this medical trial is currently recruiting participants; it was originally published in December 1st 2022, with the most recent update occurring November 30th of the same year. In total, 20 individuals need to be sourced from a single site."
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