Your session is about to expire
← Back to Search
Gossypol + Lenalidomide + Dexamethasone for Multiple Myeloma
Study Summary
This trial is testing the side effects and best dose of R-(-)-gossypol acetic acid given with lenalidomide and dexamethasone to treat patients with multiple myeloma that has returned or gotten worse after treatment.
Timeline
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Trial Design
Find a Location
Who is running the clinical trial?
Media Library
- You have a condition called monoclonal gammopathy of undetermined significance (MGUS) or smoldering myeloma.You have already tried more than three different treatments for multiple myeloma.You have another type of cancer that is currently being treated, except for non-melanoma skin cancer or early-stage cervical cancer. If you had cancer in the past, you are not currently receiving treatment for it.I'm not sure what specific criterion you are referring to. Can you provide more details or context?You have other health problems that would make it difficult for you to take part in the trial, like uncontrolled infection or serious heart or lung disease.You are not currently receiving any other experimental treatments, but you can still take bisphosphonates for support.You had a severe skin reaction to similar drugs before.You have medical issues that make it unsafe for you to take medicine to prevent blood clots while being treated with lenalidomide.You have current heart problems that are not under control, such as irregular heartbeat, heart failure, chest pain, or heart attack within the last 6 months.You have been diagnosed with HIV.Your kidneys are working well enough, with a clearance of at least 60 mL of creatinine per minute.You must have a certain level of white blood cells called neutrophils in your body.Your platelet count is at least 75,000 per cubic millimeter.Your hemoglobin level is at least 8.0 grams per deciliter.You have multiple myeloma that has come back and is causing symptoms.You must have a measurable disease of multiple myeloma, which means that it can be seen and measured by the doctors.Your blood test shows high levels of certain proteins and an unusual ratio of other proteins.You have a high level of a specific type of protein in your blood.You have more than 200 milligrams of monoclonal protein in your urine over a 24-hour period.You are able to perform daily activities without any problems (ECOG performance status 0, 1, or 2).You have already been treated with at least one previous medication.Women who can have babies must have a negative pregnancy test within 7 days before joining the study.You agree to give samples of your bone marrow and blood for research.
- Group 1: Treatment (AT-101, lenalidomide, and dexamethasone)
- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
Are applications for this clinical trial still being accepted?
"As indicated by the information on clinicaltrials.gov, recruitment for this trial has concluded and no more candidates are being sought at present. Originally posted on April 14th 2016, it was most recently updated November 9th 2022 - though there are 1,504 other trials that remain open to participants."
How many subjects are being monitored for this research endeavor?
"This research project is no longer looking to enroll patients. Initially posted on April 14th 2016, and most recently edited November 9th 2022; if you are seeking alternative trials, presently 807 multiple myeloma studies and 697 Pharmacological Studies have open enrollment periods."
What sorts of disorders have been effectively addressed with Pharmacological Study?
"Pharmacological Study is a viable treatment for ophthalmia and sympathetic. Furthermore, it has been prescribed to manage angina pectoris, two prior rounds of chemotherapy, as well as branch retinal vein occlusion."
What other investigations have been conducted related to Pharmacological Study?
"Currently, there are 697 active trials that focus on Pharmacological Study with 166 of those investigations in their third phase. Most of the studies take place in Joliet, Illinois but it is not the only location - 25,511 sites are conducting research for this field."
To what extent are people exposed to potential risks when participating in a Pharmacological Study?
"Our assessment gave Pharmacological Study a score of 1 on the safety scale as it is a Phase 1 trial, which implies that there are only scant data points indicating its efficacy and safety."
Share this study with friends
Copy Link
Messenger