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Dual Variable Domain Immunoglobulin

ALPN-202 for Lymphoma (NEON-2 Trial)

Phase 1
Waitlist Available
Research Sponsored by Alpine Immune Sciences, Inc.
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up up to 6 weeks following study day 1
Awards & highlights

NEON-2 Trial Summary

This trial will test how well increasing doses of a new drug work against advanced solid tumors or lymphoma in adults.

Eligible Conditions
  • Lymphoma
  • Solid Tumors

NEON-2 Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~up to 6 weeks following study day 1
This trial's timeline: 3 weeks for screening, Varies for treatment, and up to 6 weeks following study day 1 for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Adverse Events (AEs)
Dose-limiting Toxicities (DLTs)
Laboratory Abnormalities
Secondary outcome measures
Objective response

Side effects data

From 2024 Phase 2 trial • 57 Patients • NCT03004183
21%
Fatigue
13%
Nausea
11%
Back pain
9%
Shortness of Breath
9%
Anemia
9%
Abdominal pain
9%
Diarrhea
7%
Pneumonia
7%
Kidney Injury and/or Infection
7%
Dyspnea
7%
Weight Loss
5%
Malnutrition, Hypercalcemia and Weakness
5%
Pneumothorax
5%
Intractable pain, back pain, hip pain
5%
Activated partial thromboplastin time prolonged
4%
Pleural effusion
4%
Atrial fibrillation with rapid ventricular response
2%
Thrombocytopenia
2%
Respiratory failure
2%
Skin rash
2%
colitis
100%
80%
60%
40%
20%
0%
Study treatment Arm
Single Arm

NEON-2 Trial Design

1Treatment groups
Experimental Treatment
Group I: Dose Escalation and ExpansionExperimental Treatment2 Interventions
ALPN-202 + pembrolizumab KEYTRUDA®

Find a Location

Who is running the clinical trial?

Merck Sharp & Dohme LLCIndustry Sponsor
3,888 Previous Clinical Trials
5,055,054 Total Patients Enrolled
91 Trials studying Lymphoma
8,736 Patients Enrolled for Lymphoma
Alpine Immune Sciences, Inc.Lead Sponsor
8 Previous Clinical Trials
557 Total Patients Enrolled
1 Trials studying Lymphoma
62 Patients Enrolled for Lymphoma
Stanford Peng, MD, PhDStudy DirectorAlpine Immune Sciences, Inc.
1 Previous Clinical Trials
62 Total Patients Enrolled
1 Trials studying Lymphoma
62 Patients Enrolled for Lymphoma

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Does my current health status meet the criteria for this research trial?

"This clinical trial is accepting 29 adults aged 18-80 who have been diagnosed with lymphoma. The enrollees must also meet the following criteria: an ECOG performance status grade of 0-1, available tumor biopsy to represent their condition, life expectancy over 3 months and eligibility for treatment with a PD-1 or PD-L1 inhibitor, previous experience with at least 2 systemic anti-cancer therapies (lymphoma subjects only), recovery from non-laboratory toxicities resulting from prior anticancer therapy up to Grade ≤ 1 (with exceptions like alopecia and hearing loss) and adequate baseline function in terms of he"

Answered by AI

Does this clinical trial include geriatric participants?

"Participants in this medical trial must be between the ages of 18 and 80. However, there are 587 trials specifically for minors and 4705 clinical studies targeting those aged 65 or over."

Answered by AI

To what extent could ALPN-202 put patients at risk?

"As this is a phase 1 trial, the safety of ALPN-202 has been approximated at 1 on the scale of 1 to 3 due to limited clinical data regarding its efficacy and security."

Answered by AI

What pathologies have been most effectively addressed by ALPN-202?

"ALPN-202 is commonly prescribed for the treatment of cancerous tumors, but can also be employed to combat unresectable melanoma and microsatellite instability high in addition to disease progression from chemotherapy."

Answered by AI

How many individuals are partaking in this research endeavor?

"At the present moment, this research project is not seeking out any new participants. This clinical trial was originally published on June 22nd 2021 and had its most recent update on November 8th 2022. For those looking for other options, there are 4059 studies actively recruiting patients with lymphoma and 961 trials that require ALPN-202 participants."

Answered by AI

How many sites are currently hosting this trial?

"Currently, this medical trial is being conducted in 7 locations - with Boston, Cleveland and Grand Rapids among them. To limit travel needs while taking part in the study, it's important to select a site closest to you."

Answered by AI

Are new volunteers still being accepted for the research program?

"This trial is no longer accepting participants; the original posting was made on June 22nd 2021, and it had its last amendment recorded on November 8th 2022. Alternative studies for lymphoma are abundant with 4059 clinical trials actively enrolling patients and 961 trials recruiting interested individuals to take part in ALPN-202 research."

Answered by AI

What other investigations have been conducted concerning ALPN-202?

"As of the present time, there are 961 ongoing studies for ALPN-202 with 122 trials in Phase 3. Houston, Texas is a primary hub for these clinical trials but they can also be found across 35731 unique locations worldwide."

Answered by AI
~8 spots leftby Apr 2025