Study to Evaluate the Effect of Aficamten Administration on QT/QTc Interval
Trial Summary
Do I need to stop my current medications to join the trial?
The trial protocol does not specify whether you need to stop taking your current medications. However, since the study is for healthy participants, it's likely that you should not be on any regular medications.
What safety data exists for Aficamten Administration or similar treatments?
How does the drug flibanserin differ from other treatments for hypoactive sexual desire disorder?
Flibanserin is unique because it is specifically designed to be taken at bedtime, which is different from other treatments that may not have specific timing requirements. It also carries a warning about the risk of severe low blood pressure and fainting when used with alcohol, which is a consideration not typically associated with other treatments for this condition.678910
What is the purpose of this trial?
This trial tests aficamten, a drug, to see how it affects the heart's electrical activity. Healthy participants are used to get clear results without other health issues interfering. The study checks if aficamten changes the heart's rhythm.
Research Team
Cytokinetics, MD
Principal Investigator
Cytokinetics
Eligibility Criteria
Inclusion Criteria
Exclusion Criteria
Timeline
Screening
Participants are screened for eligibility to participate in the trial
Part A: Dose Finding
Open-label, single ascending dose study to identify the dose for Part B
Part B: TQT Study
Randomized, double-blind, placebo- and positive-controlled, single-dose, 3-way crossover study to evaluate the effect of aficamten on QT/QTc interval
Follow-up
Participants are monitored for safety and effectiveness after treatment
Treatment Details
Interventions
- Aficamten Administration
Find a Clinic Near You
Who Is Running the Clinical Trial?
Cytokinetics
Lead Sponsor