HOPO 14-1 for Chemical Toxicity Safety Study
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial is testing a pill called HOPO 14-1 in healthy people to see if it is safe and well-tolerated. The pill helps remove harmful radioactive substances from the body.
Do I have to stop taking my current medications for the trial?
The trial requires that you stop using laxatives, antibiotics, and antacids within 7 days of dosing. If you are taking any investigational drugs, you must stop them 60 days before dosing or 5 half-lives of the drug, whichever is longer.
Who Is on the Research Team?
Principal Investigator
Principal Investigator
SRI International
Are You a Good Fit for This Trial?
Healthy individuals who understand the study, can consent to it, and follow its rules. They must use contraception if applicable, have a body weight of 50-110 kg (or BMI ≤ 40 if over 110 kg), and test negative for drugs unless prescribed. People with certain lab abnormalities, heart issues, recent illness or transfusions, difficulty swallowing pills, or positive tests for hepatitis B/C, HIV or COVID-19 cannot join.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive a single oral dose of HOPO 14-1 in varying doses across different cohorts
Follow-up
Participants are monitored for safety, tolerability, pharmacokinetics, and excretion after receiving the dose
What Are the Treatments Tested in This Trial?
Interventions
- HOPO 14-1
Find a Clinic Near You
Who Is Running the Clinical Trial?
SRI International
Lead Sponsor